CURRENT STEM CELL NEWS

1. Researchers successfully treat Parkinson's disease using stem cell in mice

Human embryonic Stem Cell- hESC-derived midbrain dopamine (mDA) or cortical glutamate neurons repaired circuits and Restored Neural Function in a mouse based Parkinson's disease (PD) model. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Study create roadmap for reprogramming of human somatic cells & develop placenta

Scientists have been able to generate a high-resolution roadmap for the transcription-factor-mediated reprogramming of human adult stem cells and have been able to directly reprogram these cells into induced trophoblast stem cells to create placenta. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. 3D model to study molecular events underlying human axial symmetry breaking

Human embryonic stem cells have been used to generate an in vitro three-dimensional model of a human epiblast which could serve as an assay to study the molecular events underlying human axial symmetry breaking during embryonic development. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. 'Cellular compass' guiding stem cell division in plants discovered

By monitoring leaf development in the flowering plant Arabidopsis thaliana, scientists have discovered that a process of two oppositely oriented nuclear migrations govern stem cell division. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Suppression of inflammation and fibrosis enhances cardiac stem cell therapy - shows study

Suppression of inflammation and fibrosis using soluble epoxide hydrolase (sEH) enzyme inhibitors (sEHIs) has resulted in increased survival of the transplanted human induced pluripotent stem cell derived‐cardiomyocytes (hiPSC‐CMs) in a murine postmyocardial infarction model. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. World first iPS cell treatment for immune disease

Induced pluripotent stem cells (iPSCs) derived mesenchymal stem cells have been used to treat acute steroid-resistant graft versus host disease in a phase I human clinical trial. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Study offers new insights into metabolic aspects of leukemia recurrence

A study has shown that lysophospholipid metabolism is required for maintenance of chronic myelogenous leukaemia stem cells and this gives new insights into the mechanism of this cancer's recurrence that is independent of oncogene. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Bioreactor based stem cell pluripotency control

A stirred suspension bioreactor environment has been demonstrated to help maintain a naïve-like pluripotent state of human pluripotent stem cells . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Metabolic pathway controlling hair stem cells deciphered

Scientists have identified that Glutamine metabolism controls stem cell fate and long-term maintenance of hair follicle stem cells which could help in hair loss treatments. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Protein employed to regulate cellular plasticity

Scientists have been able to regulate cellular plasticity by inhibiting a protein called CDK8 which stabilized the Pluripotent stem cells (PSCs) in the naive state Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Scientists have used MRI scans and computer modelling to pinpoint areas of the human brain that regulate fatigue. This finding could help in developing strategies to improve people's performance.
 -Source: ScienceDaily, 26 August 2020 and Nature Communications, 2020; 11 (1)

2. Did you know that a weighted blanket could help you sleep better? Scientists in a study on 120 adults diagnosed with clinical insomnia and a co-occurring psychiatric disorder have discovered that using a weighted chain blanket significantly reduced insomnia severity and reduced symptoms of fatigue, depression and anxiety. This could underlie the logic of "holding environment" theory, which states that touch is the basic need which provides calming and comfort to humans.     
-Source: ScienceDaily, 23 September 2020 and Journal of Clinical Sleep Medicine, 2020; 16 (9): 1567

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