CURRENT STEM CELL NEWS

1. ‘Self eating’ process of stem cells key to the regulation of embryonic stem cells

Chaperone-mediated autophagy (CMA) is the key factor regulating embryonic stem cell self-renewal and differentiation, according to a new study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Scaffold cultured stem cells promote diabetic wound healing

A bioengineered scaffold device of dermal matrix, human mesenchymal stem cells, and a drug called timolol has been found to promote diabetic wound healing in mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Diabetic drug stimulates endogenous stem cells to treat paediatric brain damage

A drug called metformin which stimulates endogenous neural precursor cells (NPCs) has been shown to promote cognitive function in a clinical trial on long-term survivors of pediatric brain tumors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Interferon-γ (IFN-γ) promotes MSC efficacy in patients with rheumatoid arthritis

Interferon-γ (IFN-γ) has been used to improve the clinical efficacy of mesenchymal stem cell (MSC) transplantation (MSCT) in patients with rheumatoid arthritis (RA). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Dermal exosomes promotes hair regeneration

Dermal papilla (DP) exosomes containing a specific microRNA miR-218-5p have been found to promote hair regeneration by regulating β-catenin signaling. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Umbilical cord blood stem cell treatment for rare genetic diseases

Allogenic umbilical cord blood transplant has been found to be a readily available source of stem cells to safely and effectively treat various noncancerous genetic disorders in a clinical study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. miRNA based novel technology to increase quality of stem cells

CA miRNA‐based strategy has been shown to enhance pluripotent stem cells (PSCs) potency by resetting their epigenetic state leading to improved stem cell therapies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Glycan profile of skin stem cells serve as potential biological marker of aging

Comprehensive glycan profiling of epidermal stem cells from young and old mouse skin revealed a significant difference in the glycan profiles between them. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Researchers grow functional liver endothelial cells from pluripotent stem cells

Functional liver sinusoidal endothelial cells have been generated from human pluripotent stem-cell-derived venous angioblasts. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Goosebumps related to hair follicle growth through stem cells – says study

The arrector pili muscle and sympathetic nerves which underlie goosebumps form a dual-component niche that modulate hair follicle stem cell activity via synapse-like contacts, according to a study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. A study designed to investigate brain connectivity in 130 mammalian species has shown that brain connectivity levels are equal in all mammals, i.e the information travels from one location to another through the same number of synapses. The difference lies in the strategies used to preserve this equal measure of overall connectivity among brains of different species.
 -Source: ScienceDaily, 20 July 2020 and ature Neuroscience, 2020; 23 (7): 805

2. Third party mediation in resolving couple conflicts is advantageous, say scientists. Romantic love activates the reward circuit in the brain. Now researchers have found that mediation by a third party during conflicts between a couple actually activates the same reward circuit and this makes these couples more satisfied after the resolution of the conflict than those who didn't receive mediation. This study opens new avenue for brain behavioural studies concerning reward circuits and neurons concerning emotions.     
-Source: : ScienceDaily, 29 July 2020 and Cortex, 2020; 130: 302 DOI: 10.1016/j.cortex.2020.04.036

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