CURRENT STEM CELL NEWS

1. Genetically edited stem cells to reverse diabetes

Gene correction was done in fibroblast-derived induced pluripotent stem cells (iPSCs) which were then differentiated to pancreatic β cells. The gene-corrected β cells were able to reverse hyperglycemia after their transplantation into diabetic mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Scientists identify the exact timepoint when embryonic stem cells differentiate

By combining single-cell imaging, genomic approaches, and mathematical modeling,scientists have been able to identify that a gene called GATA3 mediates a fast and irreversible Commitment of differentiation in human embryonic stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Third FDA-approved Clinical Trial for COVID-19

A third clinical trial on stem cells that uses Autologous Mesenchymal Stem Cell Therapy (HB-adMSCs) has been approved by the USA for COVID-19. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Astrocytes in Brain are key to learning and memory – says study

Astrocytes which are supportive cells of the brain actually play an important role in a wide variety of complex and essential functions, including the regulation of neuronal circuits involved in learning and memory. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Sperm stem cell treatment for male infertility

Autologous spermatogonial stem cell (SSC) transplantation has been shown to rescue congenital male infertility caused by Cldn11 deficiency in mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Small molecule rescues telomere deficiency in aged iPSCs

A small-molecule called PAPD5 inhibitor BCH001 has been able to restore telomerase activity and telomere length in dyskeratosis congenita patient derived induced pluripotent stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. iPSC derived neuron can restore neural circuitry in stroke – proves study

Human iPS cell–derived cortical neurons when transplanted in brains of rats with ischemic lesions in the cerebral cortex showed extensive morphological and functional integration of axonal projections. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Protein that blocks the ability of heart muscle to regenerate discovered

A protein called calcineurin has been identified to play a key role in blocking the ability of heart muscle to regenerate after the first week of life. Further scientists discovered that calcineurin regulates two other proteins called Hoxb13 and Meis1 whose deletion was able to extend the postnatal window of cardiomyocyte proliferation and reactivate the cardiomyocyte cell cycle in the adult heart. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. CAR-T cell therapy leads to complete remission in B-Cell Malignancies

Anti-CD22 chimeric antigen receptor (CAR) T-cell therapy has led to complete remissions in 70% of patients with anti-CD19-resistant acute B-cell leukemia in a multi centric clinical trial. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Transient expression of reprogramming factors reverse aging in adult cells

Transient expression of nuclear reprogramming factors has resulted in resetting of epigenetic clock and reversal of aging in chondrocytes and aged human muscle stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know the human language's evolutionary origins traces back to 25 million years? Yes, neuroscientists have made this discovery by brain imaging study and analysis of auditory regions and brain pathways in humans, apes and monkeys.
 -Source: ScienceDaily, 20 April 2020 and Nature Neuroscience, 2020; DOI: 10.1038/s41593-020-0623-9

2. New study shows that if you fast, you tend to sleep early and better. The study says, sleep is a function of the body trying to conserve energy and so in case of fasting, since energy stores are getting depleted fast, the body tends to sleep. Further, lack of sleep makes you obese, according to the same study.     
-Source:ScienceDaily, 22 April 2020 and PLOS Biology, 2020; 18 (4): e3000220

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