CURRENT STEM CELL NEWS

1. Fat rich food promotes regeneration of intestinal stem cells

Compared with mice that were fed a regular diet, a fat rich diet gave adult stem cells in the intestine a regenerative boost that improving their ability to recover from damage to the intestinal lining. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Mutation in mitochondria behind iPS cells' rejection

Scientists have found evidence in mice and humans that de novo mutations occur in mitochondria during reprogramming to the induced pluripotent stem cell stage and this process produces neoantigens capable of eliciting immune recognition and rejection of the iPS cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Nanotechnology platform helps detect stem cells

A multifunctional magneto-plasmonic nanorod (NR)-based detection platform , which uses special tiny rods for sensing, has been found to aid in confirming the identity of human stem cell fates and their biomarkers without destroying them. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Novel CRISPR screens for screening iPS derived neurons

While most previous CRISPR-based screens were conducted in cancer cell lines rather than healthy, differentiated cells, a novel CRISPR interference (CRISPRi)-based platform has been developed for genetic screening of human neurons derived from induced pluripotent stem cells (iPSCs). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Niche stiffness determines neural stem cell aging

Microenvironment of Brain stem cells known as oligodendrocyte progenitor cells (OPCs) stiffens with age and this mechanical change has been found to cause age-related loss of function of OPCs. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. RNA methylation determines blood stem cells' symmetrical division

Using single-cell RNA sequencing (scRNA-seq) and transcriptomic profiling of HSPCs (hematopoietic stem and progenitor cells) scientists have found that methylation marks known as m6A when knocked out the hematopoietic stem cells (HSCs) fail to symmetrically differentiate. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Cancer stem cell contribute to angiogenesis also in tumours

Cancer stem cells in addition to giving rise to the primary cancer cells of a tumour also can morph into special cell types that build tiny bunches of blood vessel within the tumour, according to a study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Researchers create early embryo structures from mouse stem cells

Researchers have generated 3D blastocyst-like structures from mouse pluripotent stem cells and these blastocysts were able to even induce proper changes in the uterus after being implanted in pseudo-pregnant mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Stem cells for tooth repair

A new population of mesenchymal stromal cells have been identified in a continuously growing mouse incisor model and these cells have been shown to contribute to the formation of dentin, the hard tissue that covers the main body of a tooth. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Optochemogenetics for stroke recovery

Selective excitation of transplanted induced pluripotent stem cell-derived neural progenitor cells (iPS-NPCs) tagged with bioluminescent luciferase was able to recapitulate an activity-enriched microenvironment which enhances regenerative benefits for the treatment of stroke. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. As a reply to why and how some people seem to have an answer to every general knowledge question, scientists have identified using magnetic resonance imaging that the brains of people with excellent general knowledge are particularly efficiently wired..
 -Source: ScienceDaily, 31 July 2019 & European Journal of Personality, 2019; DOI: 10.1002/per.2217

2. A DNA mutation in the mitochondrial genome which can harm only the male offspring has been discovered in Drosophila thus proving true the 'Mother's curse hypothesis' which states that moms may transmit genes to their children that harms their sons but not their daughters    
-Source: ScienceDaily, 2 August 2016 and eLife, 2016; 5 DOI: 10.7554/eLife.16923

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