CURRENT STEM CELL NEWS

1. iPS stem cell therapy to repair brain damage

Researchers have shown that human-induced pluripotent stem cells derived glial enriched progenitor cells transplantation shortly after stroke were able to have a therapeutic effect by maturing into astrocyte cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Matrisome gene assessment and insights into stem cell potency

Assessment of genes that regulate matrix formation "matrisome genes" has revealed that collagen IV plays an important role in regulating how pluripotent stem cells' divide and differentiate in the planarian flat worm. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Dental atlas of stem cells that make the human teeth mapped

Single cell analysis has revealed the first comprehensive dental atlas of the pulp and periodontal tissues of human teeth in which it has been found that molecular signatures of the various stem cell populations were very similar but the differences arose due to microenvironmental changes. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. New Therapeutic Target for improve muscle stem cell in type 2 diabetes

A gene called VPS39 which helps muscle stem cells to create new mature muscle cells is impaired in Type II diabetes and hence people with type 2 diabetes (T2D) have poorer muscle strength and quality. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Vision restored with pluripotent stem cell derived eye cells

Transplantation of purified human pluripotent stem cell-derived cone photoreceptors has helped restore vision in an animal study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Placenta and amniotic cells demonstrated in synthetic embryos in lab

Researchers have been able to show the presence of precursors of the placenta and the amniotic sac in synthetic embryos from mouse stem cells, which was a challenge earlier. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Neuromuscular junctions (NMJs) model created in lab

In the neuro-degenerative disease, Amyotrophic lateral sclerosis (ALS), Neuromuscular junctions (NMJs) are affected. A lab model of a human neural motor unit has been created to investigate the effects of ALS-causing mutations in NMJ. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Gene loss in cerebellum and autism pathogenesis deciphered

Mutations in a gene encoding for the chromatin remodeler chromodomain helicase DNA-binding protein 8 (CHD8) has been shown to regulate the proliferation and differentiation of granule neuron progenitors (GNPs) and plays an important role in cerebellar development which in turn has been implicated to autism pathogenesis.. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Pancreatic organoids with ducts and gland cells created in vitro for the first time

Scientists have developed the first-of-its-kind organoid model of the pancreas which includes both the acinar and ductal structures and this model will serve as a renewable source for modeling pancreatic diseases including cancer. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Cord blood stem cell derived vesicles to treat lung fibrosis

Umbilical cord blood stem cell derived extracellular vesicles have been shown to reducee pulmonary fibrosis by inhibiting transforming growth factor-ß signaling. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Research has shown that intermittent fasting is beneficial by reducing blood pressure in hypertension by modulating the composition of gut microbiota..
 -Source: ScienceDaily, 29 April 2021 and Circulation Research, 2021; DOI: 10.1161/CIRCRESAHA.120.318155

2. Did you know that your desire for coffee is driven by your genes? Yes, a study on 390,435 people has shown that there is genetic evidence for cardiovascular system–driven influence on coffee intake wherein people tend to naturally regulate their coffee consumption based on blood pressure levels and heart rate..    
-Source: ScienceDaily, 28 April 2021 and The American Journal of Clinical Nutrition, 2021; DOI: 10.1093/ajcn/nqab014

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