CURRENT STEM CELL NEWS

1. Nucleosides help pluripotent stem cell to combat stress

Culturing the human pluripotent stem cells with exogenous nucleosides has helped reduce the extent of DNA replication stress, DNA damage, and consequent aberrant mitoses, resulting in improved survival, clonogenicity, and population growth... Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Clinical trial for baldness shows positive outcome

A randomised clinical trial on adipose‐derived stem cell constituent extract (ADSC‐CE) has helped in hair regrowth in patients with androgenetic alopecia (AGA). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Mechanism of how Amniotic stem cells reduce pulmonary fibrosis deciphered

Mesenchymal stromal cells derived from the human amniotic membrane (hAMSCs) reduce pulmonary B‐cell recruitment, thereby reducing the progression of the fibrotic lesion in pulmonary fibrosis Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Rejuvenating fibroblasts by mechanical reprogramming

Fibroblasts have been rejuvenated by reprogramming them in an optimized 3D collagen matrix, making these cells more contractile and more efficient at synthesizing matrix components. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Embryonic stem cell transplantation in new born for liver disease accomplished

A new born baby in Japan has received world's first embryonic stem cell treatment in new born, for liver disease as a bridging treatment till liver transplant can be done. Click to read more...

6. Researchers design better model of early brain in lab using stem cells

Microfluidic-controlled stem cell regionalization (MiSTR) has helped model a neural tube in vitro which will help understand processes behind rostro-caudal neural tube patterning. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Nutrient availability determines cancer stem cell fate during tumour initiation

Extracellular availability of an amino acid called serine is a critical determinant of epidermal stem cells (EpdSCs) fate which are cell of origin for squamous cell carcinoma and serine starvation has been found to antagonize squamous cell carcinoma growth. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Glial progenitors offer hope for multiple Sclerosis

Human glial progenitor cells transplanted to brains of myelin-deficient shiverer mice have been able to remyelinate even diffusely demyelinated adult CNS offering hope to repair the brain cell damage caused by multiple sclerosis (MS). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Intravenously delivered mesenchymal stem cells helps prevent microvessel obstruction in heart disease

Mesenchymal stem cells (MSCs) by their immunomodulatory activity have been able to attenuate Microvascular obstruction (MVO) in a porcine model of myocardial ischemia and reperfusion (I/R) injury. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. SARS-CoV-2 affects lung stem cells – says study

Four different lung epithelial stem cell types have been shown to express SARS-CoV-2 entry factors, including Ace2 thus causing these stem cells when infected by SARS-CoV-2, to become defective leading to the severity of SARS-CoV-2 infection and its consequences. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Favourable genetic variants that were introduced into modern humans by mixing with Neandertals, including one for progesterone receptor is the cause behind one in three European women with increased fertility, fewer bleedings during early pregnancy and fewer miscarriages.
 -Source: ScienceDaily, 26 May 2020.and Molecular Biology and Evolution, 2020; DOI: 10.1093/molbev/msaa119

2. Even a single meal high in saturated fat will hinder our ability to concentrate, says a new study and this is important especially during the COVID-19, because of changes in people diet when they work from home.     
-Source: ScienceDaily, 12 May 2020 and The American Journal of Clinical Nutrition, 2020; DOI: 10.1093/ajcn/nqaa085

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