Journal of Stem Cells and Regenerative Medicine

News Letter - 31                       vol.2; iss.14                              27 July 2011



1. Seventh and eighth bases of DNA identified –Potential implications in Cell fate reprogramming and cancer

For decades it was thought that DNA consists of four basic units -- adenine, guanine, thymine and cytosine and recently it was discovered that there are fifth and sixth bases of DNA. As an addition to that discovery scientists have now identified the seventh and eighth bases of DNA and this is important in advancing stem cell research because these bases could be important for cell fate reprogramming and cancer. Click to read more...

2. 'Organizer' Cells orchestrate the shape formation of an embryo

To verify whether "organizer" cells of the embryo really posses a true organizing ability, scientists have transplanted human organizer cells, derived from human embryonic stem cells into frog’s embryo and to their astonishment, it was observed that these frogs had two neural tubes, one tube made of frog cells and the other made of transplanted human cells.Click to read more...

3. Researchers generate first genome-wide mapping of a DNA modification in human embryonic stem cells

Stem cell researchers have generated the first genome-wide mapping of a DNA modification called 5-hydroxymethylcytosine (5hmC) in embryonic stem cells and found that it is predominantly found in active genes. This is important because until now, researchers didn't know where 5hmC was located within the genome and this may also prove to be important in controlling diseases like cancer. Click to read more...

4. “Super Gene” to improve the iPS reprogramming process

University of Minnesota Medical School researchers have used a “super gene” approach by fusing two proteins – a master stem cell regulator (Oct4) and a fragment of a muscle cell inducer (MyoD) to improve the efficiency of reprogramming and purity of the reprogrammed iPS cells.Click to read more...

5. Long term results of study on autologous stem cell therapy for metastatic breast cancer yields positive results

Long term results of a study that took place in the late 90s on treating Stage IV breast cancer patients with high-dose chemotherapy followed by a rescue with autologous purified blood stem cells have now been published and the results show that this therapy offers benefits. Click to read more...

6. Human Chondrocytes grown in 3D culture using polymer scaffold without growth factors

An Indo-Japan joint team has used a novel 3D TGP scaffold prepared by the Polymer scientists from Waseda University, Japan and has accomplished in vitro expansion of human chondrocytes grown to a macroscopically viewable tissue for more than 90 days expressing the appropriate phenotype markers.Click to read more...

7. Skin cells to brain cells: p53 at crossroads between stem cells and cancer cells

Scientists have successfully converted human skin cells into brain cells by suppressing the expression of p53 and their study suggests that p53 suppression may cause the cell to either become a cancer cell or a stem cell depending on the environment. Click to read more...

8. Mesenchymal stem cells fuel up cancer

In a study published online in the Journal of Clinical Investigation, researchers have identified that the mesenchymal stem cells which are normal cells found throughout the body actually fuel up the cancer in the ovarian tumors.Click to read more...

9. Exploring the memory of Stem Cell to treat diabetes

Tel Aviv University researchers have harnessed the memory retaining capacity of stem cells to develop potential therapies for diabetes. They say when induced pluripotent stem cells are created from pancreatic beta cells( the cells responsible for the production of insulin) these pluripotent cells prove more efficient than their embryonic counterparts in creating insulin-producing cells.Click to read more...

10. Studying genetic diseases by targeting pluripotent cells

Using two distinct methods, Whitehead Institute researchers have successfully manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. This site specific gene modification technology could help to fix disease-causing mutations before the cells could be transplanted into patients or to create cell lines that researchers can use to study genetic diseases in future.Click to read more...

11. Neural stem cells depend on their ugly siblings ‘the ependymal cells’

The question of why neural stem cells in a lab dish don't continue to make neurons as they do inside the brain has been answered by the finding that neural stem cells depend on their neighboring ependymal cells to make new neurons and at present when neural stem cells are harvested for growth in culture the ependymal cells are not removed along with them which decreases the ability of neural stem cells to produce neurons in culture.Click to read more...

12. Fibroblast growth factor determines cell fate of developing heart cells

Researchers have identified that 'fibroblast growth factor' (Fgf) is the controlling switch that can direct developing heart cells to become either new heart muscle or blood vessels and this discovery will one day help in generation of tissues to repair the human heart after a heart attack.Click to read more...


1. Did you know that the 1926 Nobel Prize in Physiology or Medicine went to Johannes Andreas Grib Fibiger, "for his discovery of the Spiroptera carcinoma", a microbial parasite which Fibiger claimed was the cause of cancer

  2. During the five-year Beagle expedition, Darwin shipped home 1,529 species preserved in spirit and 3,907 labelled skins, bones and other dried specimens




1. BIT 1st Annual World Congress of Molecular & Cell Biology (CMCB-2011)
August 6-8, 2011, Beijing, China. For details Click here

2. World Stem Cell Summit;
October 3-5, 2011, Pasadena,CA. For details Click here

3. NCRM N I C H E 2011- Sixth Anniversary of Nichi-In Centre for Regenerative Medicine
Fujio Cup Quiz 2011, Plenary Session and Symposium on "Stem Cell and Regenerative Medicine",
15th October 2011, Chennai, India. For details click here

4.2nd International Conference on Stem Cells and Cancer (ICSCC-2011)
Oct 15 -19 - Pune, India.  For details Click here

5. 2nd meeting of ACTO (Asian Cell Therapy Organization)
October 17-20, Miyazaki Prefecture, Japan. For details Click here


Quote Corner:

“No individual has any right to come into the world and go out of it without leaving something behind. ”

- George Washington Carver



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