CURRENT STEM CELL NEWS

1. Common anti-emetic drug inhibits proliferation of leukemia stem cells

A commonly prescribed anti-emetic, metoclopramide has been shown to block CD93 which promotes stemness and self-renewal of leukemia stem cells (LSCs) in chronic myeloid leukemia. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. iMS- Induced multipotent stem cells to enhance regenerative therapies

Researchers have optimized culture conditions to reprogram human adipocytes into induced multipotent stem (iMS) cells and these novel cells could help regenerate tissues in a context-dependent manner without ectopic or neoplastic growth. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Scientist use stem cells to regenerate cranial suture defects

In mice with craniosynostosis having increased intracranial pressure and neurocognitive behavioral abnormalities, a biodegradable material combined with mesenchymal stem cells have been shown to regenerate a functional cranial suture that corrected the skull deformity, normalized intracranial pressure, and rescued neurocognitive behaviour deficits. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Viral infection induced protein de-regulation promotes cancer stem cell evolution

Pro-inflammatory cytokine-responsive base deaminases actually are believed to restrict viral replication. Now it has been identified that Inflammation-dependent base deaminases such as the APOBEC3C actually promote human pre-leukemia stem cell (pre-LSC) evolution to acute myeloid leukemia stem cells (LSCs) thereby leading to therapeutic resistance. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Autologous stem cell transplant in multiple sclerosis produces positive outcome – proves long term follow-up

Autologous hematopoietic stem cell transplantation (aHSCT) has been shown to prevents disability worsening and induces durable improvement in disability in patients with multiple sclerosis (MS), in a study which reported the long term outcome. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Retinal stem cell transplants show successful engraftment and outcome in primate study

Human retinal pigment epithelium (RPE) stem cell-derived RPE (hRPESC-RPE) transplantation under the macula of a non-human primate model for 3 months has been observed to recover in vivo and maintain healthy photoreceptors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Blood stem cell nice protein crucial for stem cell renewal- says study

A protein called netrin-1 produced by the stem cell niche has been identified to play key role in preserving quiescence and self-renewal of blood stem cell via neogenin-1 function. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Red blood cell progenitor produced growth factor for stem cell mobilization

A fibroblast growth factor-23 (FGF23) produced by erythroblasts, precursors of red blood cells has been reported to promote the mobilization of hematopoietic stem cells into the peripheral blood. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Designer DNA segments for cancer therapies

A "designer" DNA segment has been proven to prevent malignant myeloma regeneration via cell cycle disruption, as well promoting sensitivity to myeloma drugs in pre-clinical models Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Mathematical model developed to predict dose of stem cell- gene therapy for HIV

Autologous, CCR5 gene-edited stem cell transplantation being a promising strategy for achieving HIV remission, a mathematical model that recapitulates blood T cell reconstitution and plasma simian-HIV (SHIV) dynamics has been developed which can the predicts ideal dose of these stem cells to achieve HIV remission. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that our brains generate a common code to mark where other people are in relation to ourselves. This is important for activities which require people to constantly navigate around other people in the same place.
 -Source: ScienceDaily, 23 December 2020 and Nature, 2020; DOI: 10.1038/s41586-020-03073-y

2. It has now been discovered that it is not the way how the genes are made of but the way how they are regulated in the brain which makes humans different from chimpanzee as there is only 1% difference between the human and chimpanzee's protein-coding genomes.    
-Source: ScienceDaily, 16 December 2020 and Science Advances, 2020; 6 (48): eabc9863 DOI: 10.1126/sciadv.abc9863

Creative Commons License All site content, except where otherwise noted is licensed under a Creative Commons Attribution 3.0 Unported License.