CURRENT STEM CELL NEWS

1. New cytoskeleton targeted technique to human stem cells into insulin-producing cells

Researchers have created pancreatic β cells with improved in vitro and in vivo function, from human pluripotent stem cells (hPSCs) by depolymerizing the cytoskeleton. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Study reveals precise details of somitogenesis in developing mouse embryo

By comparing mouse gastruloids with mouse embryos using single-cell RNA sequencing and spatial transcriptomics, researchers have been able to study somitogenesis in unprecedented detail. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Molecular motors for stem cell control

Molecular motors have been used to direct the fate of human bone marrow–derived mesenchymal stem cells (hBM-MSCs) to form osteoblasts. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Study find connection between intestinal bacteria & blood stem cell transplant recipients

The composition of the intestinal microbiota has been found to be connected to the risk of gram-negative bloodstream infections during allogeneic hematopoietic cell transplantation.. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Drugs to mobilize bone stem cells for healing after surgery

β3 adrenergic agonists (β3AR) in combination with a CXCR4 antagonist, AMD3100/Plerixafor has been found to be able to mobilise mesenchymal stromal cells into the blood which could be utilized to hasten bone healing. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Brain organoids help study effects of common anti-depressant on developing baby's neurons

Developmental neurotoxicity (DNT) of a common SSRI prescribed for depression during pregnancy has been studied using organotypic human induced pluripotent stem cell (iPSC)-derived brain model (BrainSpheres). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. MicroRNA control of process essential to placenta growth in early pregnancy deciphered

Researchers have studied how a primate-specific microRNA cluster on chromosome 19 (C19MC) regulates epithelial-to-mesenchymal transition (EMT), a process contributing to placental implantation during early pregnancy as well as cancer progression . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Neural inputs to accelerate 3D bioprinted skeletal muscle's regeneration

By integrating neural input into 3D bioprinted skeletal muscle constructs have resulted in improvement of myofiber formation and neuromuscular junction formation in vitro. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Novel technology maps genome-wide RNA–chromatin interactions

To investigate the function of tens of thousands of noncoding RNAs encoded by the Mammalian genomes, researchers have employed a technology called RADICL-seq that maps genome-wide RNA–chromatin interactions in intact nuclei. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Fat availability determines fate of skeletal progenitor cells – says study

Obstruction of blood vessel invasion during bone healing favours chondrogenic over osteogenic differentiation of skeletal progenitor cells through Sox9 and this process is driven by lower concentration of fats in that location. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that breathing may change your mind's decisions? Yes, Scientists have shown that the likelihood of initiating a voluntary decision is higher when we exhale. This breathing pattern related action coupling could be used in research and diagnostic tools for patients with deficits in voluntary action control, like obsessive compulsive disorders, Parkinson disease etc.
 -Source: ScienceDaily, 6 February 2020 and Nature Communications, 2020; 11 (1)

2. Your gut microbiota influences your body's chemistry. Researchers have found that gut microbiota modify bile acids of the host with other amino acids -- phenylalanine, tyrosine and leucine thereby influencing liver and intestine function.     
-Source: ScienceDaily, 26 February 2020 and Nature, 2020; DOI: 10.1038/s41586-020-2047-9

Creative Commons License All site content, except where otherwise noted is licensed under a Creative Commons Attribution 3.0 Unported License.