CURRENT STEM CELL NEWS

1. Cell lineage tracing identifies reason behind smell deterioration in older age

Researchers by tracking the development of stem cells in the brains of mice using confetti reporters have reported that the ability of self-renewal of neural stem cells declines in old age, especially in the transit amplifying progenitors which cause fewer cells to differentiate into olfactory cells (cells responsible for smell) in old age. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Sperm cell number maintenance mechanism studied

It has been identified that sperm stem cell number is maintained by a subset of lymphatic endothelial (LE) cells which produce FGFs. Stem cells which consume more FGFs are likely to duplicate, and those that consume less differentiate. These stem cells compete with each other for a limited supply of FGFs which helps maintain the stem cell number to automatically adjust to a particular value, depending on the rate of FGF supply. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Neural plate stem cells generated from skin cells

By reprogramming, adult human fibroblasts and blood cells have been induced to form induced neural plate border stem cells (iNBSCs) which were able to give rise to generate functional cell types of neural crest and central nervous system lineages. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Faster Accurate method to examine cardiac muscle cells reported

CRISPR-Cas9, a genome-editing tool has been used to generate a calcium-indicating reporter stem cell line which would help in faster and more accurate method of examining the effectiveness of human pluripotent stem-cell-derived cardiac muscle cells.Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. iPS derived neuron treatment for epilepsy

When human induced pluripotent stem cell (hiPSC)-derived medial ganglionic eminence (MGE) cells were grafted into the hippocampus after epilepsy they were able to greatly reduce the frequency of spontaneous seizures. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Two different mechanisms control neural stem cell differentiation – says study

Scientists have identified two distinct control mechanisms in the developmental transition of undifferentiated stem cells into brain cells. The study has observed that a protein called PRC1 represses neuronal function related genes by adding a molecule called ubiquitin in early stages of brain development while in later stages of astrocyte differentiation ubiquitin-adding activity becomes unnecessary and PRC1 becomes clusters (polymers) on these genes. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Gene playing key role in myelination of neurons studied using stem cells

Previosuly unknown role of transcription factor known as PRRX1 in human oligodendrocyte progenitor cells which generate myelin-forming oligodendrocytes has been studied in which it has been found that PRRX1 induces a gene expression signature characteristic of stem cell quiescence and this pathological quiescence of progenitors could prevent regeneration in Multiple sclerosis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. New drug as maintenance therapy after stem cell treatment for multiple myeloma studied in clinical trial

A clinical trial has established that maintenance therapy with a drug called Ixazomib following autologous stem cell transplantation (ASCT) can delay disease progression and prolong survival in patients with multiple myeloma. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Reprogrammed stem cells transplanted to Parkinson patient in world's first clinical trial

Scientists at Kyoto University Japan have transformed induced pluripotent stem (iPS) cells into precursors to the neurons and have implanted these 'reprogrammed' stem cells into the brain of a patient with Parkinson's disease for the first time. Click to read more...

10. Cytokine helps combat GVHD after blood stem cell transplant

Using a mouse model researchers have shown that stem cells transplanted in blood stem cell transplant produce large amounts of GM-CSF during graft-versus-host responses and if the mice were given donor cells that were unable to produce GM-CSF they were protected against the lethal response. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that bees can count? Yes. Research has shown that Bees with very small numbers of nerve cells in their brains can actually solve seemingly clever counting tasks.
 -Source: ScienceDaily, 21 December 2018 and iScience, 2018; DOI: 10.1016/j.isci.2018.12.009

2. Scientific results suggest that mothers may pass on personality traits and relationship skills which will influence their children's likelihood of forming stable relationships.     
-Source: ScienceDaily, 13 November 2018 and PLOS ONE, 2018; 13 (11): e0205732 DOI: 10.1371/journal.pone.0205732

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