CURRENT STEM CELL NEWS

1. MSCs prove safe in clinical trial for multiple sclerosis

Mesenchymal stem cells (MSCs) have been found to be safe and has been found to delay disease progression in people with active, progressive multiple sclerosis (MS). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Organoids of foregut and midgut created in lab

Using induced pluripotent stem cells (iPS), scientists have successfully grown functional organoids of foregut and midgut giving rise to connected set of organs including a liver and a pancreas connected by a bile duct. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Variation in protein concentration affects stem cell fate

It has been found that temporal fluctuations in protein concentrations of SOX2 and OCT4 can determine the type of cell that embryonic stem cells will become. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. miRNA pathways regulating pluripotency in embryonic stem cells deciphered

High-content screening of human pluripotent cells studied the effects of 31 miRNA-regulated pathways in controlling pluripotency and differentiation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Bone marrow cells used to treat ischemic stroke in Clinical trial

A single‐arm, phase I clinical trial of intravenous (IV) administration of autologous bone marrow mononuclear cells (MNCs) after acute ischemic stroke (AIS) has shown evidence for safety and feasibility of using patients' own bone marrow cells to enhance recovery after ischemic stroke. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Chronic sinusitis leads to loss of smell due to stem cell identity change – says study

Neuronal stem cells responsible for the sense of smell have been observed to transform themselves to a different identity perpetuating the long-term inflammation in chronic sinusitis and this process leads to loss of smell which will be restored once the inflammation settles down. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. CRISPR edited stem cells for lifelong correction of muscular dystrophy

CRISPR editing of muscle stem cells (MuSCs) with adeno-associated virus serotype-9 (AAV9) have been shown to hold promise for sustained gene repair therapy for muscular dystrophies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Researcher find key role of PIWI proteins in extraordinary regeneration potential of planaria

Planarians recruit piRNAs for mRNA turnover in adult stem cells which is the key mechanism behind the extraordinary regeneration potential of planarian neoblasts. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Engineered T Cells provide long term iNKT cells for cancer

Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer. Hematopoietic stem cell-engineered iNKT (HSC-iNKT) cell therapy has been established which can provide therapeutic levels of iNKT cells for a patient's lifetime. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Exosomes can be the solution for youthful skin- suggests study

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids have been found to be more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments currently in use. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Some Sleep to Remember, Others to Forget, Yes, scientists have observed distinct patterns of electrical activity in the sleeping brain that may influence whether we remember or forget what we learned the previous day and in a rat study by tweaking these brainwaves while animals slept, scientists were able to influence how well rats learned a new skill.
 -Source: ScienceDaily, 3 October 2019 and Cell, 2019; 179 (2): 514 DOI: 10.1016/j.cell.2019.08.040

2. Did you know getting multiple tattoos can help you avoid cold? Yes receiving multiple tattoos can strengthen your immunological responses via the "inoculation hypothesis" , potentially making you heartier in fighting off common infections, according to research.     
-Source: ScienceDaily, 8 March 2016. and American Journal of Human Biology, 2016; DOI: 10.1002/ajhb.22847

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