Journal of Stem Cells and Regenerative Medicine

News Letter - 51                       vol.3; iss.12                              25 Jul 2012



1. Aging related mutation, a major cause for leukemia

Research has identified that Blood stem cells keep acquiring mutations with age and the mutational history of the cell is captured, as the clones expand, after which only two or three additional genetic changes are required to transform such a normal blood cell already having mutations into the deadly blood cancer, the acute myeloid leukemia (AML). Click to read more...

2. Flamingo and Frizzled 8 make blood stem cells to sit still when they are not needed

Researchers at the Stowers Institute for Medical Research have identified that two molecules called Flamingo (Fmi), and Frizzled 8 (Fz8) play an important role in maintaining the quiescent state of mouse blood-forming stem cells when the function of these cells are not required. This study will pave for future studies in identifying how the quiescent stem cells in the aged can be activated. Click to read more...

3. Placenta-derived progenitor cells have more blood vessel forming capability than Umbilical cord blood derived cells

A study comparing the endothelial progenitors derived from human placenta or those derived from human umbilical cord blood has identified that placental progenitors have more blood vessel forming ability in vivo than Umbilical cord blood progenitors. These placental endothelial progenitors may be of help in treating neonatal cerebral ischemia and cardiovascular diseases in the future. Click to read more...

4. Targeting a Inflammatory pathway may help overcome Herceptin resistance of Breast Cancer Stem cells

Treatment with the drug Herceptin has dramatically improved outcomes in Breast cancer patients but the hurdle is the cancer cells become resistant to Herceptin easily. Now scientists have identified the pathway how this resistance develops and have suggested ways as to how it can be overcome. Click to read more...

5. New research offers insights into the pluripotency of embryonic stem cells

Research employing molecular, microscopic and genomic approaches at the Hebrew University of Jerusalem has offered insight into the mechanism behind the ability of embryonic stem cells to renew themselves indefinitely and to differentiate into all types of mature cells. Click to read more...

6. Modified Stem cells for enhanced cardiac repair

Cardiac stem cells from the aged patients with heart disease were isolated and modified using a protein which promotes cell survival and growth. These modified stem cells when injected into immunocompromised mice showed better efficacy and enhanced cardiac repair, according to a study done by researchers from San Diego. Click to read more...

7. Critical protein needed for Blood Stem Cell development identified

A team led by Dr Anna Bigas, at the IMIM has identified a critical protein needed for development of blood stem cells from embryonic stem cells and this research will help in future to generate blood stem cells from other stem cells like the embryonic stem cells in the lab .Click to read more...

8. Blood vessels created from fat stem cells could pave way for 'off the shelf' vessel grafts

Fat stem cells obtained from liposuction procedures has proven to be useful in creating blood vessels in the lab which can be used as grafts in procedures like by-pass surgery.Click to read more...

9. RhoC induces Breast Cancer Stem Cell metastasis - Says study

A cancer gene called RhoC has been linked with the aggressive spread of breast cancer and an inhibitor to target this gene is being developed at the University of Michigan Comprehensive Cancer Center. Click to read more...

10. Follow-up of the first stem cell - supported tracheal transplant patient shows positive findings

A follow-up report published in Lancet of the patient who was transplanted with a donor trachea coated with the patient's own stem cells two years ago has showed that the patient is healthy and there is no rejection of the transplanted trachea. Click to read more..


1. We all know that all organisms have a unique genetic code which is the code or information carried in the DNA. This genetic code should be termed as the first genetic code or the original genetic code because the scientists have deciphered a second genetic code too. The second genetic code is responsible for the final assembly of proteins inside living cells, and it works with the original genetic code.

2. Are you aware that Astronauts in space will have weakened immune systems than on earth because the immune cells like T- cells do not proliferate properly in space? It means, in space , the astronauts will be increasingly vulnerable to infections from new exposures and also, the pathogens already present in the body which would normally be suppressed might become active leading to further infections.




1. SPINE 2012 , 13 - 16th September, 2012, Le Royal Meridian, Chennai For details Click here.

2. NCRM NICHE 2012, 13 Oct, 2012, Savera Hotels, Chennai For details Click here.

3. Nov 29-30, 2012; 7th Annual ConGress of the German Ssociety for Stem Cell Research, Leipzig, Germany. For details Click here.


Quote Corner:

“Education is what remains after one has forgotten everything he learned in school”

- Albert Einstein


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