CURRENT STEM CELL NEWS

1. Single cell transcriptomics gives 3D atlas of bone marrow

Combined single-cell and spatial transcriptomics as helped reveal the molecular, cellular and spatial organization of the bone marrow niche. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Epigenetic defects in stem cells and Psoriasis – Study reveals link

Loss of 5-hmC has been associated with dysregulated epidermal stem cell kinetics to produce the classic psoriatic epidermal architecture. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Self-assembling hydrogel advance tissue engineering approach

Self-assembling Peptide‐programmed hydrogels have been employed to provide the three equal and essential requirements of protection, support, and survival of cells for tissue engineering. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Granulosa cells reprogrammed to form oocytes using chemicals

Functional oocytes have been generated from adult female somatic Granulosa cells through reprogramming by chemical treatment alone Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Scientist find new subtype of muscle stem cell

Researchers have identified PAX7-negative human muscle-derived cell colonies and these cells were able to regenerate muscle after reinjury thus debunking the concept that PAX7 is essential for muscle regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Blood stem cell marker behind adult haematopoiesis identified

ESAM (Endothelial cell-selective adhesion molecule), a surface marker for hematopoietic stem cells (HSCs) has been identified to play an important role in the development of definitive adult-type erythropoiesis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Cardiac progenitor cells turned to pace maker cells

Human cardiac progenitor cells (CPCs) have been reprogrammed to sinoatrial node (SAN) cells which form the pace maker of the heart using trio combination of transcription factors such as SHOX2, TBX3, TBX5, TBX18, and the channel protein HCN2. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Bone marrow stem cells give hope for bone genetic disorder

Bone marrow stromal cells in a bone directed transplantation approach has been found to engraft and improve bone formation in osteogenesis imperfecta. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Gene modified blood stem cells for sickle cell anaemia proves successful in clinical study

CD34-positive cells gene modified to form fetal hemoglobin have been found to produce improvements in fetal hemoglobin and other hematologic measures among five patients who were transplanted. Click to read more...

10. Human tracheal tissue bioprinted

A tracheal tissue construct comprised of multiple different functional materials has been bioprinted in whcih different designs of smooth muscle and cartilage regions in artificial tracheal substitutes have been created with similar mechanical properties to human tracheal tissue. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Temporary sight deprivation can actually help hearing-impaired people adapt to cochlear implants and hearing aids, according to a study which found that a week in the dark rewires brain cell networks and changes hearing sensitivity in adult mice
 -Source: ScienceDaily, 4 December 2019 and eNeuro, 2019; ENEURO.0269-19.2019

2. Little exercise during developmental period may actually extend lifespan. Oxidative stress experienced early in life has been shown to extend lifespan in C. elegans. Thus, in humans too, exercise and calorie restriction when young which can lead to Oxidative stress may actually help them live longer, if these results are extrapolated.     
-Source: ScienceDaily, 4 December 2019 and Nature, 2019; DOI: 10.1038/s41586-019-1814-y

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