CURRENT STEM CELL NEWS

1. Study identifies novel target for blood stem cell expansion ex vivo

By inhibition of an epigenetic regulator, researchers have been able to induce a rapid expansion of human cord blood derived CD34+ cells and promotes in vitro propagation of long-term repopulating blood stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Magnetic control of stem cells therapies for chronic lung diseases

Magnets have been used for in vitro guidance of magnetized mesenchymal stem cells and to enhance their retention in the lungs in vivo. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Researchers create highly potent stem cell from iPS cells for treating complex bone fracture

A highly osteogenic Mesenchymal stem cells (MSCs) line has been generated from induced pluripotent stem cells that could generate high yields of bone yielding cell matrix in vitro. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Gene edited stem cell model for retinal disease

iPSC-Derived Retinal Organoids have been used to model and rescue RP2 Retinitis Pigmentosa. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Researcher produce fish germline stem cells in vitro

Researchers have reported a novel method of in vitro expansion of germline stem cells (GSCs) from fishes which could aid in rescuing fishes that are on the verge of extinction. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Improved targeting of stem cells in leukaemia

A novel method that uses an antibody treatment (anti-RSPO3) to interfere with the interaction between two key molecules driving the cancer stem cell's self-renewal process has been reported which could help treat acute lymphoblastic leukaemia (ALL). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Enhanced anti-tumor activity of NK cells produced from iPSCs

A specific gene knocked out Natural Killer (NK) cells have been produced from induced pluripotent stem cell which exhibited improved expansion and increased cytotoxic activity against multiple tumor cell lines. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Molecular landscape of birthplace of blood stem cells explored

Researchers have characterized the molecular topography of the of the aortic microenvironment, where the first hematopoietic stem cells (HSCs) are generated during development. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. 3D bladder cancer organoid created

A specific organoid culture method has been used to create 3D bladder cancer organoids using cells from dogs with bladder cancer and these organoids have been explored to find out how they could serve as useful tools for cancer research and therapy. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. World's first Covid-19 patient derived stem cell transplant for thalassemia

Doctors have been able to use stem cells from a young patient with coronavirus disease, to help his sister who has thalassemia. Click to read more...

Really???

1. Your neighbourhood influences your genes. Yes, a long-term study of 2,000 children has found that young adults raised in communities marked by more economic deprivation, physical dilapidation etc display differences in the epigenome and this could explain how long-term health disparities among communities emerge
 -Source: ScienceDaily, 19 June 2020 and JAMA Network Open, 2020; 3 (6)

2. Did you know how the very first proteins formed on earth around 3.7 billion years looked like? Researchers have reconstructed protein sequences that resemble those ancestors of modern proteins and this research throws more light on how those primitive proteins could have progressed to forming living cells.     
-Source: ScienceDaily, 22 June 2020 and Proceedings of the National Academy of Sciences, 2020; 202001989

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