CURRENT STEM CELL NEWS

1. Longevity Gene plays critical role in regulating brain stem cells' renewal

A gene called Forkhead box protein O3 (FOXO3) which is linked to unusually long lifespans has been found to be critical in regulating long-term regenerative potential of brain stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Allogenic umbilical cord stem cells demonstrate better cartilage regeneration potential than bone marrow aspirate

Allogeneic human umbilical cord blood-derived mesenchymal stem cells transplantation in high tibial osteotomy with microfracture for medial unicompartmental osteoarthritis of the knee has shown better outcome than bone marrow aspirate concentrate in a human clinical study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Autologous MSCs Study show efficacy in ischemic stroke

Application of preconditioned, autologous mesenchymal stem cells (MSCs) with autologous serum has been found to be safe and result in improvement in patients with chronic major stroke.. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Bioengineered hybrid muscle constructs for muscle regeneration

Engraftment of bioengineered hybrid muscle constructs made of muscle extracellular matrix (MEM) and induced skeletal myogenic progenitor cells (iMPCs) have been shown to induce de novo muscle regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Crosstalk between cancer stem cells and macrophages fuels cancer – says study

A complex crosstalk exists between cancer stem cells (CSCs) and tumor-associated macrophages (TAMs) which establish a tumor microenvironment to protect and promote CSCs development and dissemination. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Proteins needed for proper skin development explored

Polycomb complexes which are groups of proteins that maintain gene expression patterns havee been found to be essential for proper skin development and this study will help to create skin in the lab in future to treat burn victims and patients with skin-blistering disorders. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Reprogrammed stem cells help create therapies for Christianson syndrome (CS)

Five induced pluripotent stem cell (iPSC) lines generated from patients with Christianson syndrome (CS), a neurological disease associated with reduced brain growth has helped to explore CRISP-R gene editing to correct the mutation associated with the disease and also therapies that involve delivery of trophic factors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Cytokinin – the key to plant stem cell division

A study has reported how cytokinin regulates stem cell division in plants by shuttling proteins into the nucleus where they activate genes involved in mitosis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Single infusion of autologous MSCs effective in spinal cord injury– study reports

A single infusion of intravenous infusion of autologous mesenchymal stem cells (MSCs) cultured in auto-serum has been shown to produce significant functional improvement in patients with SCI. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Stem cells + Bacterial nanocellulose (BNC)- An eeffective combination to treat eye damage

Human embryonic stem cells‐derived Limbal stem cells (hESC‐LSC) have been transplanted using Bacterial nanocellulose (BNC) as a vehicle for ocular surface regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. A study has shown that uninterrupted sleep is vital for the brain's ability to connect a fear memory to the sensory event. This finding is helpful in understanding PTSD or generalized anxiety because disruption of sleep in such individuals make their brain to understand fear but not process the cause of the fear.
 -Source: ScienceDaily, 22 February 2021 and Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-21471-2

2. Similar to how LEGO blocks can be arranged to form new structures, a recent study has shown that genetic elements called transposons, or "jumping genes," get continuously combined into the process of mixing of genes during evolution giving rise to new genes by a process called exon shuffling.    
-Source: ScienceDaily, 22 February 2021. Science, 2021; 371 (6531): eabc6405 DOI: 10.1126/science.abc6405

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