CURRENT STEM CELL NEWS

1. Blood vessel organoids grown in lab to serve as model of Diabetic vasculopathy

Organoids grown using human stem cells in the lab were able to recapitulate the structure and function of human blood vessels and have been found to be amenable to serve as a model for identifying the regulators of diabetic vasculopathy. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. New approach of cell therapy for diabetes

A new differentiation strategy involving transforming growth factor β (TGF-β) signaling has been used to enhance the efficiency of stem cell-derived β (SC-β) cells which when transplanted greatly improved glucose tolerance in Diabetic mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Stem cell transplant to help multiple sclerosis

A study has compared nonmyeloablative autologous hematopoietic stem cell transplantation (HSCT) with disease-modifying therapy for patients with highly active relapsing-remitting multiple sclerosis (MS) and reported the outcome. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Embryonic stem cells help discover antibody treatment for ovarian cancer

Human embryonic stem cells have been used as immunogen to generate monoclonal antibodies against ovarian cancer. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Cellular map of wood formation from stem cells studied

Using pulse labelling and genetically encoded lineage tracing, scientists have discovered that a single bifacial stem cell generates both xylem and phloem cell lineages in plants. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Failure of neural stem cells to provide support leads to Alzheimer's suggests study

A study has shown that there is age-dependent dysfunction of neural progenitor cells , with loss of immune-modulatory and neurotrophic properties, induced by the pathological Alzheimer's brain environment and this makes the stem cells unable to support the brain cells during the degeneration process. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. iPS cell derived clinical grade RPE patch rescues retinal function in rats

CD34+ peripheral blood cells from patients with age-related macular degeneration (AMD) were used to generate oncogenic mutation-free clinical-grade iPSCs which were then used to create clinical-grade RPE cell patches. These RPE patches had therapeutic effects in rodent and pig models of retinal degeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Molecular control of macroscopic forces driving embryonic stomach formation studied

The molecular control of macroscopic forces which act in early morphogenesis of the gut tube in the chick embryo has been studied providing insight into the early gut development. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. 3D printing to regenerate the spinal cord

A microscale continuous projection printing method (μCPP) has been employed to create scaffolds which were then loaded with neural progenitor cells (NPCs). These cell laden scaffolds were found to support axon regeneration and form new 'neural relays' in complete spinal cord injury in rodents. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Japan approves stem cell treatment for spinal cord injury

Japan's health ministry has given conditional approval for the treatment, called Stemirac which takes autologous mesenchymal stem cells (MSCs) from the patient with spinal cord injury and expanded MSCs are intravenously infused back into patients 40 days after their injury to help repair the damage. Click to read more...

Really???

1. A pre-biotic molecule known as glycolonitrile (HOCH2CN) discovered recently in a solar-type protostar known as IRAS16293-2422 B could shed light on how life emerged on Earth, according to the new research.
 -Source: ScienceDaily, 23 January 2019 and Letters, 2019; 484 (1): L43

2. Deep learning algorithms have been for the first time applied to study human evolution and the process has revealed in the genome of Asian individuals, the footprint of a new unknown species who could be an ancestor to modern humans.     
-Source: ScienceDaily, 16 January 2019 and Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-018-08089-7

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