CURRENT STEM CELL NEWS

1. Geometrical control for efficient production of cardiomyocytes

Fast-paced improvement of geometrical control to influence the formation of formation of Embryoid Bodies (EBs) has resulted in more efficient production of cardiomyocytes . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Successful implantation specialized grafts of neural stem cells for SCI

In vivo imaging has demonstrated host-to-stem cell graft synaptic connectivity after neural stem/progenitor cell (NSPC) transplantation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Optic nerve lamina region identified as neural progenitor niche

Optic nerve lamina region has been identified as a neural progenitor cell niche and its age related depletion may explain development of diseases like open angle glaucoma (OAG) according to a study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Speech recovered in ALS patients after stem cell therapy

Speech recovery has been observed after autologous bone marrow-derived lineage negative (LIN-) cells administration into cerebrospinal fluid (CSF) in Amyotrophic lateral sclerosis (ALS) patients. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Mitochondria's status determines stem cell fate in early brain development

Differentiation of stem cells of early brain development depends on mitochondria wherein cells that have fragmented mitochondria shortly after mitosis more likely develop to neurons while cells undergoing mitochondrial fusion are likely to continue being stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. New way to prevent cancer cells from becoming chemo-resistant

In order to prevent cancer cells becoming chemotherapy resistant, timed cell-intrinsic or niche-focused metabolic disruption can help by inducing metabolic collapse, says study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Efficient Strategies for Microglia Replacement devised

Bone marrow transplantation (mrBMT), microglia replacement by peripheral blood (mrPB) and microglia replacement by microglia transplantation (mrMT) have been compared to find the most efficient strategy for replacement of microglia, which are immune cells of the central nervous system. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. OvCa-Chip microsystem recapitulates tumor microenvironment of ovarian cancer

OvCa-Chip that includes cocultures of cancer and vascular cells, and platelet flow has helped to serve as a model for platelet extravasation through the endothelium into tumors enabling to study mechanisms of the cancer-vascular-hematology nexus for designing proper therapies Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Gene editing enables long term engraftment of blood stem cells for treating blood disorders

Gene editing using CRISPR-Cas9 of hematopoietic stem cells to reactivate production of fetal hemoglobin (HbF) for a long time has been achieved in nonhuman primates and this will serve as a potential treatment strategy for hemoglobinopathies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. First-ever functional miniature human hearts created in the lab

The most faithful recapitulation of human cardiovascular development to date has been demonstrated in an in vitro organoid model using human pluripotent stem cells (hPSCs) in the lab. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. It is all in the gut. Now researchers have identified that gut bacteria is essential for immunotherapy in cancer to work as production of the metabolite inosine by these gut bacteria enhances the immunotherapy's efficacy by working on anti-tumor T cells.
 -Source: ScienceDaily, 13 August 2020 & Science, 2020; eabc3421

2. Since our perceptual and motor systems are intertwined during emotional processing of stimuli when we smile, we are more likely to see the world around us in a positive way, says a new study.     
-Source: : ScienceDaily, 13 August 2020 & Experimental Psychology, 2020; 67 (1): 14

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