CURRENT STEM CELL NEWS

1. Enzyme which awakes brain stem cells discovered

Researchers have identified how to wake up dormant neural stem cells in the furit fly Drosophila. They have identified that Histone monomethyl transferase Pr‐set7 is required for the stem cells to exit from quiescence. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Macrophages serve as niche for muscle stem cell regeneration

A recent study suggests that it is a specific subset of macrophages that dwell within the place of muscle injury which establish a transient but obligate niche for muscle stem cell proliferation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Continuous hair follicle regeneration achieved

A method has been developed to help continuous cyclical regeneration of cultured hair follicles (HF) from hair follicle stem cells to to achieve HF regenerative therapy. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Lab model of Enterocyte-like cells developed from pluripotent stem cells .

Human-induced pluripotent stem cells (iPSCs)derived enterocyte-like cells have been created in the lab which can be used as a model for the evaluation of drug and metabolism studies of the human small intestine. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. First "atlas" of bone marrow tissue constructed

Cell-by-cell analysis techniques have been employed to construct the first "atlas" of bone marrow tissue which will help to understand how tiny blood vessels organize the bone marrow and regulate how blood cells get produced. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Stem cells reprogrammed from fat cells regenerate tissues in lab model

Terminally differentiated murine osteocytes and adipocytes have been reprogrammed into induced multipotent stem (iMS) cells which have been shown to contribute directly to muscle, bone, cartilage, and blood vessels, with no evidence of teratogenic potential in a xenograft model. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. CRISPR-Cas9 knockout screening to study gastric tissue cells

Genome-scale CRISPR-Cas9 knockout screening applied on three-dimensional ex vivo stomach organoids has provided important mechanistic insight into Wnt-dependent epithelial cell renewal in mouse gastric epithelia. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Current status of cell therapies for Parkinson's disease (PD) reviewed

The Scientific Issues Committee on behalf of the International Parkinson and Movement Disorder Society (MDS) has reported a brief review of the current status of cell-based therapies in Parkinson's disease (PD) from recognized international experts. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Signalling pathway crucial for regulation of blood cancer stem cells deciphered

A signalling pathway called LIGHT/LTβR pathway has been identified to be an important pathway in the regulation of the self-renewal of blood stem cells and leukemic stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Fat stem cell therapy for treating lymphedema after breast cancer

In a phase I clinical trial with 4 years of follow‐up, axillary delivered Adipose‐derived regenerative cells and lipotransfer has been useful in alleviating breast cancer‐related lymphedema. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know it was a single base-pair alteration in the genome of our predecessors such as the Neanderthals that made us humans with modern capabilities in social behavior, language, adaptation, creativity and use of technology?
 -Source: ScienceDaily, 11 February 2021. and Science, 2021 DOI: 10.1126/science.aax2537

2. The frequency of daytime naps if it all a person takes depends on their genes, says new research and this study will help in understanding more about associations of daytime naps with cardiometabolic health concerns, such as large waist circumference and elevated blood pressure and personalized recommendations for seista in the future.    
-Source: ScienceDaily, 10 February 2021. and Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-020-20585-3

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