CURRENT STEM CELL NEWS

1. Patient derived stem cell model offers clues for Parkinson treatment

Using a patient-based in vitro model of reprogrammed stem cells, researchers discovered exonic splicing mutation in the gene called PARK7 linked to Parkinson's disease and this study will help in designing precision targeting therapies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Scientist create surrogate male animals using stem cell from donor animals

In male mice, pigs, and goats which were rendered genetically sterile by CRISPR-Cas9 editing, researchers have transplanted sperm-producing stem cells isolated from a donor male into the testes of these sterile animals for preserving the germplasm Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Genes regulating pluripotent stem cells in mammals are surprisingly similar – reveals study

Mammalian genes in the pluripotency regulatory network across mammals has been found to show high degree of evolutionary stasis implying the conservation of this fundamental biological process across species. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Stem cell clinical trial shows remarkable outcome in autistic children

A clinical trial on autologous bone marrow mononuclear cell transplantation combined with educational intervention for children with autism spectrum disorder has resulted in remarkable decrease in repetitive behaviours and hyperactivity. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Scientist grow Intestinal grafts using stem cell from patient tissue

Researchers have demonstrated that it is possible to construct autologous jejunal mucosal grafts using biomaterials from pediatric patients and these patient-derived organoids can be expanded efficiently in vitro for treating children with intestinal failure. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Stem cell study finds possible mechanism behind high colorectal cancer incidence in men

The roles of androgen in proliferation and differentiation of intestinal stem cells via targeting of the androgen receptor (AR) on intestinal stromal cells has been explored which has highlighted the fact that stromal cells constitute the intestinal stem cell niche which could possibly explain the higher incidence rates of colorectal cancer in men. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Precise Microscale gel deposition to control single cell functions

A unique droplet microfluidic technique to deposit a defined amount of 3D hydrogel matrices around single cells has been developed which can be used to control Mesenchymal stem cells (MSCs) fate in vitro. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Scientist study mutations behind ovarian cancer using stem cells

In a recent study, scientists have studied the effects of genes that are commonly mutated in High-Grade Serous Ovarian Carcinoma on ovarian surface epithelium stem cells (OSE-SCs) or non-stem cells (OSE-NSs) and have found that ovarian surface epithelium stem cells transform more efficiently than non-stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Metabolic reprogramming of neural stem cells triggering tumorigenesis deciphered

A study on neural stem cells has found that metabolic reprogramming induced by mitochondrial fusion of tumour initiating cells is rate-limiting for their immortalization triggering their irreversible dedication to tumorigenesis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Functional loss of a single gene leads to deadly brain cancer- suggests study

Inactivation of a single called gene SMARCB1 affects the neural development and causes atypical teratoid rhabdoid tumors, according to a study.. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. The presence of second X chromosome in women gives them more protection in Alzheimer's, making them survive longer with less severe symptoms than men because a potent variant of a gene called KDM6A that contributes to resilience against Alzheimer's disease is present only on the X chromosome.
 -Source: ScienceDaily, 26 August 2020 and Science Translational Medicine, 2020; 12 (558): eaaz5677

2. If your mind can unconsciously predict complex patterns, you are more likely to believe in God because a neuroscience study done using implicit pattern learning to investigate religious belief has shown that individuals who have the ability to unconsciously predict complex patterns, are likely to believe with more conviction that there is a God who creates patterns of events in the universe.     
-Source: ScienceDaily, 9 September 2020 and Nature Communications, 2020; 11: 45030

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