CURRENT STEM CELL NEWS

1. Human segmentation clock modelled in vitro

Human presomitic mesoderm (PSM) cells derived in vitro—have been used to recapitulate the oscillations of the segmentation clock for the first time. This segmentation process is the critical step that leads to pairs of somites rhythmically produced. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Stem cell treatment compared with best available therapies in landmark trial for multiple sclerosis

Researchers have begun trial testing of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) against the best available biologic therapies for severe forms of relapsing multiple sclerosis (MS). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Key pathway in deadly gastric cancer identified

Osteopontin (OPN) -CD44 pathway has been identified in gastric squamous-columnar junction (SCJ) cancer that provides a promising target for developing potential therapies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. 3D atlas of bone marrow: new understanding of stem cell environment

Combined single-cell and spatial transcriptomics has helped reveal the three-dimensional organisation of bone marrow and this has provided a novel scientific basis to study blood cancer. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Radical treatment of oral infection actually not needed before stem cell transplantation – says study

Acute and chronic oral foci of infections, decayed, missing or filled tooth index (DMFT) and periodontitis have been observed to not be associated with survival or infectious complications including sepsis during the 6-month follow-up period after Haematopoietic stem cell transplantation (HSCT) in a study and hence scientists advocate that radical treatment of oral infection before HSCT is not actually needed. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Human T cell genesis studied using pluripotent stem cells for the first time

Human T-cell genesis has been examined using pluripotent-stem-cell-derived haematopoietic organoids and the study revealed that a wave of human T-cell development originates directly from haemogenic endothelium via a RAG1+ intermediate with multilineage potential. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Researchers study biologic pacemaker cells creation in lab– Hope for pacemaker cell therapy

A screening strategy has been employed to test for reprogramming factors for the conversion of human cardiac progenitor cells (CPCs) into Pacemaker-like cells and this study will help develop an optimal Pacemaker-like cell-based therapy within failing hearts. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Number and type of newly born neurons studied in Zebrafish

Researchers have been able to determine the number and type of newly formed neurons in zebrafish and The scientists discovered two types of neurons that can be newly formed: Projection neurons, which create connections between brain areas, and internal neurons, which serve to fine-tune the activity of the projection neurons. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Mitochondria behind MSC's role in boosting islet cell transplantation

The stress islets undergo during preparation for transplantation compromises their functional viability. MSCs help boosting their functional capability. Now a study has reported that MSCs transfer mitochondria to islet β-cells during in vitro co-culture and this process improves the functionality of islets. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Study offers first transcriptional single-cell atlas of the developing testes during human puberty

Single-cell transcriptomes of ∼10,000 testicular cells from four boys spanning puberty was analysed and compared with those of infants and adults. The results showed that there are distinctive phases of germ cell differentiation occurring during puberty and a common progenitor for Leydig and myoid cells prior to puberty has also been identified. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. The pleasure centre of the brain that produces the chemical dopamine has been found to be linked with the brain's biological clock that regulates daily physiological rhythms and also, it has been found that high-calorie foods that bring pleasure to the brain actually disrupt normal feeding schedules therefore resulting in overconsumption and obesity
 -Source: ScienceDaily, 3 January 2020 and Current Biology, 2020; DOI: 10.1016/j.cub.2019.11.029

2. Dementia-related language symptoms actually differ based on the language as per a new study. English and Italian speakers with dementia-related language impairment were compared. English speakers had more trouble pronouncing words and tended to speak less than usual while Italian speakers with the same disorder had fewer pronunciation difficulties.    
-Source: ScienceDaily, 10 January 2020. and Neurology, 2020; 10.1212/WNL.0000000000008879

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