CURRENT STEM CELL NEWS

1. Role of Long noncoding RNAs in stem cell regulation studied

Distinct processing of lncRNA orthologs has shown to influence functional divergence of embryonic stem cells in the context of pluripotency regulation across species. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Mesenchymal stem cells maintain colon cancer cells

MSCs from different sources could promote tumor growth and create the environment that is conducive to the survival of cancer stem cells (CSCs), according to a recent research. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Local opening of chromatin promotes genetic programming in embryonic stem cells

A short α-helical region, conserved among FOXA pioneer factors has been identified to interact with core histones and contributes to chromatin opening in vitro which dictates what organs an embryo’s stem cells will give rise to. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Stem cells' role in plant branching identified

A study has shown how a key shoot stem cell-promoting gene activates its own expression which in turn maintains a stem cell lineage in the leaf axil that enables branching. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Secretome based stem cell therapy for myocardial infraction

Sustained subcutaneous delivery of the secretome of human cardiac stem cells (CSCs) has been shown to induce cardiac repair in vivo in myocardial infarction. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Novel technique helps produce retinal cell more efficiently for treating blindness

Cell surface markers of retinal pigment epithelial cells have been identified which have been used to develop a scalable monolayer differentiation protocol for growing these cells without the need for manual isolation for harvesting them. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Abnormal stem cell clones in COPD identified

COPD lung is dominated by three pathogenic stem cell variants which drive key COPD features of inflammation, fibrosis, and airway obstruction. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. UCB-MSCs for COVID-19

A clinical trial has been approved in the US to study umbilical cord-derived mesenchymal stem cells administration in COVID-19 patients to prevent lung inflammation. Click to read more...

9. Exercise rejuvenates dormant skeletal muscle stem cells by acting on Cyclin D1 - reveals study

It has been discovered that restoration of old muscle stem cells (MuSCs) activation by physical exercise occurs by restoration of Cyclin D1, whose expression declines with age in MuSCs. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Mitochondrial impairment drives Crohn’s disease recurrence

Reduced Paneth cell (PC) function contributes to the ileal pathogenesis of Crohn’s disease (CD). Researchers have shown that mitochondrial dysfunction in the intestinal epithelium leads to reduced stemness and acquisition of a dysfunctional PC phenotype. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Increased Screen time actually doesn’t impair children's social skills, says a new study in which researchers compared teacher and parent evaluations of children who started kindergarten in 1998 (six years before Facebook launched) with those who began school in 2010 (when the first iPad debuted). According to the study, both groups of kids were rated similarly on different interpersonal skills including the ability to form and maintain friendships.
 -Source: ScienceDaily, 13 April 2020 &American Journal of Sociology, 2020; 125 (4): 1030 DOI: 10.1086/707985

2. Gut feeling and intuition may be scientifically correct too, as researchers who mapped the movement of neuron-loving viruses in the rats' from small intestines all the way to the brain found that the entire brain is connected in the gut-brain axis including centres of higher emotional intelligence.     
-Source: ScienceDaily, 2 April 2020 and Autonomic Neuroscience, 2020; 225: 102656

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