CURRENT STEM CELL NEWS

1. Co-transplantation of embryonic derived epicardial cells and cardiac muscle cells improve cardiac function

Co-transplantation of human embryonic stem cell (hESC)-derived epicardial cells and cardiomyocytes resulted in doubling of cardiomyocyte proliferation rates in vivo and 2.6-fold greater cardiac engraftment. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Cell by cell study reveals new insights into immortal Hydra's regeneration

Single-cell RNA sequencing of adult Hydra which can regenerate any part of its body helped scientists identify how the animal renews all cells in its body using three stem cell populations. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Small molecule based approach help create DNA Damage-Free Induced Pluripotent Stem Cells for cardiac transplantation

Scientists have used a small molecule to activate the transcription factor p53 in induced pluripotent stem cells (iPSCs) derived cardiomyocytes (CMs) which selectively induces apoptosis in the DNA-damaged cells alone. So the spared DNA damage-free (DdF) iPSC–derived CMs were studied for engraftment into an ischemic mouse heart. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. More Progenitor cells in adults behind increased prostate growth with age

The prostates of older mice contained more luminal progenitor cells which are capable of generating new prostate tissue than the prostates of younger mice and this could be the reason why the prostate grows with age in men over age 60 leading to benign prostatic hyperplasia, or BPH. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Reactivation of fetal hemoglobin (HbF) is a treatment strategy for hemoglobinopathies

Low doses of radiation have been found to give cancer-capable cells with mutations in p53 a competitive advantage over normal cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Cellular dynamics of Sebaceous gland development traced

The cellular bases of origin of sebaceous gland (SG) is not known. Scientists applied large-scale quantitative fate mapping and found that Sebaceous gland (SG) develop from a defined number of lineage-restricted progenitors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Stimulating protective immune cells may be the key to treat auto immune diseases- suggests study

Inflammatory and suppressive immune cells balance each other and a study has suggested that selectively activating suppressive CD8 T cells may restore the balance in autoimmune disease like multiple sclerosis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Bioinspired membranes for optimising bone regeneration

Bioinspired PCL-based hybrid fibrous membranes have been developed with robust osteoinductive ability and this will be highly useful for guided tissue regeneration applications without the need to use growth factors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Scientists create implantable blastocysts in lab

Induced self-organizing 3D blastocyst (BC) like cysts (iBLCs) have been generated from mouse pluripotent stem cells (PSCs) culture in vitro Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. New cell type with stem cell properties identified in liver

Researchers have identified a previously unknown cell with similar properties to a stem cell by sequencing cells in human foetal liver tissue. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. As a reply to why and how some people seem to have an answer to every general knowledge question, scientists have identified using magnetic resonance imaging that the brains of people with excellent general knowledge are particularly efficiently wired..
 -Source: ScienceDaily, 31 July 2019 & European Journal of Personality, 2019; DOI: 10.1002/per.2217

2. A DNA mutation in the mitochondrial genome which can harm only the male offspring has been discovered in Drosophila thus proving true the 'Mother's curse hypothesis' which states that moms may transmit genes to their children that harms their sons but not their daughters    
-Source: ScienceDaily, 2 August 2016 and eLife, 2016; 5 DOI: 10.7554/eLife.16923

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