CURRENT STEM CELL NEWS

1. Diabetes drug to prevent allogenic stem cell transplantation rejection

Sitagliptin, a drug used for the treatment of type 2 diabetes when added to a standard immunosuppressive regimen has resulted in an impressively low incidence of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation, by inhibiting DPP-4 — a homodimeric type II transmembrane receptor. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Personalized stem cell therapy for COVID-19

A personalized cellular therapy generated by co-culture of patient's immune cells with stem cells has found to be beneficial in Acute respiratory distress syndrome (ARDS) in COVID-19. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Single-cell RNA sequencing offers insights into transcriptional states of brain cancer stem cells

Single-cell RNA sequencing on Glioblastoma stem cells (GSCs) that drive tumorigenesis from the tumors of 26 patients has revealed the gradient of Developmental and Injury Response transcriptional states that define functional vulnerabilities underlying this deadly tumour. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Fat stem cell therapies before and after COVID-19 reviewed

An article has reviewed in detail the major guidelines and differences in adipose-derived stem cell (ADSCs) processing before and after COVID-19. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Bioengineered protein 2D materials to modulate cell responses

Biologically active binary protein 2D materials have been designed to rapidly assemble into arrays which recapitulate the computational design model in vitro which can further help modulate cell responses and reshape synthetic and living systems. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Scientists create 3D cortico-motor assembloids for capturing brain and muscle interaction in vitro

Organoids derived from human induced pluripotent stem cells (hiPSCs) that resemble the cerebral cortex or the hindbrain/spinal cord have been assembled with human skeletal muscle spheroids to generate 3D cortico-motor assembloids. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Clonal hematopoiesis in hematopoietic stem cell transplantation revisited

A study has reviewed the outcomes of Clonal hematopoiesis (CH) occurring after hematopoietic stem cell transplantation, characterized by expansion of mutated hematopoietic stem and progenitor cell (HSPC) clones which has an increased risk for hematologic neoplasms and cardiovascular disease. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Novel DNA sequencing approach to pinpoint specific DNA sequences within intact cells

A novel method combining sequencing and micro-imaging called in situ genome sequencing has been used to sequence specific DNA sequences located inside intact cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Nuclear piston helps in cell migration

It has been identified that the nucleus functions like a piston to activate mechanosensitive ion channels for generating cell migration paths. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Ideal dose of stem cells for cure of HIV determined

Autologous stem cell transplants in which stem cells are removed from the patient, engineered using gene editing so that they lack CCR5, and returned to patients is in practice for treating HIV. Now researchers have identified the ideal dose of such stem cells for cure of HIV.. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. The process of how a virus assembles its daughter virions to infect other cells was a mystery so far which has now been solved and since this molecular process is genetically conserved it can be used as a potential anti-viral target.
 -Source: ScienceDaily, 8 January 2021 and PLOS Pathogens, 2020; 16 (12): e1009146 DOI: 10.1371/journal.ppat.1009146

2. Throwing light on how life could have formed on earth, researchers have identified that a simple compound called diamidophosphate (DAP) would have been present on Earth before life arose, which chemically knitted together tiny DNA building blocks called deoxynucleosides into strands of primordial DNA giving rise to life.    
-Source: ScienceDaily, 28 December 2020 and Angewandte Chemie International Edition, 2020; DOI: 10.1002/anie.202015910

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