CURRENT STEM CELL NEWS

1. In situ genome editing comes of age

A novel gene editing system has been used to test the efficiency of genome modification in situ in tissue stem and progenitor cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Expanded potential stem cells- a new paradigm in regenerative medicine

Porcine expanded potential stem cells (EPSCs) have been derived from individual blastomeres and these cells express key pluripotency genes, are genetically stable, permit genome editing, and help to derive cells & tissues of all three germ layers. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Novel technology helps create large quantities of blood stem cells in lab

A defined, albumin-free culture system has been developed to help long-term ex vivo expansion of functional mouse haematopoietic stem cells (HSCs) which will help to create vast quantities of blood stem cells for use in people with blood cancers. Click to read more...

4. Circulating exosomes help track cells transplanted to treat myocardial infarction

Exosomes from blood have been isolated to track human cardiosphere-derived cells (CDCs) and cardiac progenitor cells (CPCs) transplanted into rat hearts after myocardial infarction. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Tissue engineering to treat bowel syndrome explored

How Stem cells & tissue engineering can be used to treat children with intestinal failure has been explored in a recent article. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Study identified key stem cells that aid endometrial regeneration

Researchers have identified that CD34+KLF4+ stem cells are the ones that migrate from inside the uterine lining to help in endometrial regeneration in every menstural cycle. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Stem cell therapy for smell loss

Intranasal delivery of olfactory specific stem cells has restored Olfactory or smell Function in a rat model of Hyposmia. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. iPS based stem cell study investigates impact of e-cigarettes on cardiovascular disease

Human-Induced Pluripotent Stem Cell–Derived Endothelial Cells have been used to study the Cardiovascular Risks of E-Cigarettes especially their effects on endothelial health and endothelial cell–dependent macrophage activation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Gel based cell factor Delivery System to treat Injured Kidneys

A gel‐based delivery system has been developed for controlled delivery of trophic factors present in the conditioned medium (CM) secreted from human placental stem cells (HPSCs) to help in renal regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Stem cell hierarchy in blood vessels deciphered

Single-Cell Transcriptional Profiling of the cells in the wall of Aorta has identified a hierarchy existing from Endovascular Progenitors to Differentiated Cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know brains of birds synchronize when they sing duets? Yes, researchers in Orinthology have found in white-browed sparrow-weaver that the nerve cell activity in the brain of the singing bird changes and synchronizes with its partner when the partner begins to sing. Based on these findings researchers suspect that there might be similar mechanisms operating during social interactions in humans such as dancing with a partner.
 -Source: ScienceDaily, 12 June 2019 & Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-10593-3

2. Neurons are thought to be oldest cells in a human body. Now scientists have identified that all the cells in a specific organ are not uniformly old and there exists an age Mosaicism in organs like brain, liver and pancreas which contain populations of cells and proteins with extremely long lifespans as old as neurons while some parts in the same organ has very young cells too.     
-Source: ScienceDaily, 6 June 2019 and Cell Metabolism, 2019; DOI: 10.1016/j.cmet.2019.05.010

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