CURRENT STEM CELL NEWS

1. Improved hydrogel delivery of Stem cells for Regenerative Medicine

Bone stem cells have been shown to grow better on microporous annealed particle (MAP) hydrogels that biodegrade. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. CAR T cells for multiple myeloma

Researchers have developed CD229 CAR T cells which are highly active in vitro and in vivo against Multiple myeloma (MM) plasma cells, memory B cells, and MM-propagating cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Multidisciplinary evaluation prior to stem cell transplantation improves outcome in elderly

Multidisciplinary team clinic (MDC) evaluation for older adults before blood stem cell transplantation have been proven to reduce transplant-related morbidity and mortality. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Developmental shape shifting of cancer cells – key mechanism behind cancer metastasis

Scientists have discovered that lung cancer stem cells can shift their identity to a spectrum of developmentally primitive or stem cell-like states which is the key mechanism behind the cancer's ability to metastasize and overcome body's immune defences. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Umbilical cord blood Stem cell therapy to prevent brain damage in growth-restricted babies

In an animal study, Umbilical cord blood stem cell therapy has been shown to mitigate perinatal brain injury due to fetal growth restriction (FGR) and ventilation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Single-molecule fluorescence microscopy helps discover novel mutations in leukemic stem cells

Single-molecule fluorescence microscopy of leukemic cancer stem cells has helped observe that hyperactive JAK2 signalling pathway mutants promote dimerization which triggers activation even without the correct signals, prompting the development of blood cells to spiral out of control. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. New blood vessel disease model using iPSCs for Progeria

Hutchinson-Gilford progeria syndrome (HGPS) patients develop weakened blood vessels and atherosclerosis. Researchers have developed functional engineered blood vessels fabricated from iPSC-derived smooth muscle cells (viSMCs) and endothelial cells (viECs) of Progeria patients which has served as a blood vessel model to study the effects of the disease. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Kidney stem cells isolated from urine

Renal progenitor cells have been derived from urine and they have been proven to express pluripotency-associated proteins and stem cell markers. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Computer stimulation provides actual visual of Oct4 binding during induction of pluripotency

Computer stimulation has shown how a pioneer transcription factor Oct4 binds to nucleosomes to open chromatin and regulate gene expression in stem cells thereby taking us closer to engineer transcription factors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Microrobotic delivery of stem cells for cartilage regeneration demonstrated for the first time

Live demonstration of a microrobot stem cell navigator based delivery of therapeutic stem cells for knee cartilage regeneration in a rabbit has been accomplished. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. The long held assumption that only human brains have the unique asymmetry and primates don't have this asymmetry has been now challenged with the finding that chimpanzees, gorillas, and orangutans all have an asymmetrical brain but human brain has the most variable pattern. Also, this study tells that the unique human cognitive abilities evolved by adapting an ancestral asymmetry pattern.
 -Source: ScienceDaily, February 2020 and Science Advances, 2020; 6 (7): eaax9935

2. Amidst the Corona virus issue, scientists have identified that the people's ability to fight off the flu virus is determined by the sequence in which they are been infected by the viruses during their life, especially the first flu strain encountered in childhood. People first exposed to the less severe strain, H1N1, during childhood were less likely to end up hospitalized if they encountered H1N1 again later in life than people who were first exposed to H3N2 but people first exposed to H3N2 received extra protection against H3N2 later in life.     
-Source: ScienceDaily, 4 February 2020 and PLOS Pathogens, 2019; 15 (12): e1008109

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