CURRENT STEM CELL NEWS

1.. Reprogramming to more naïve state erases disease memory in cells – shows study

By reprogramming to a stable naïve human pluripotent stem cell state scientists have shown that it is possible to effectively erase dysfunctional epigenetic donor cell memory or disease-associated aberrations in patient-specific human induced pluripotent stem cells (hiPSC). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Egg stem cells don't exist, Single cell analysis confirms

Single-cell transcriptomes and cell surface antigen profiles of over 24,000 cells from high quality ovarian cortex samples from 21 patients has proven that there are no oogonial stem cells and there is a limited ovarian reserve. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Signal succession cascade that keeps plant stem cells active deciphered

A molecular framework linking the epidermis-derived signal to the stem cell homeostasis has been uncovered wherein that plant epidermis produces mobile signals to control this gradient and the stem-cell activity. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Stem cell therapy in utero treatments offer hope for deadly metabolic congenital diseases

In utero enzyme replacement therapy and in utero hematopoietic stem cell transplantation has been shown to improve survival and functional outcomes in Mucopolysaccharidosis type VII (MPS7) which is a rare and severe lysosomal storage disorder. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Stem cell therapy for COVID-19 pneumonia

Intravenous transplantation of Mesenchymal stem cells (MSCs) has been found to be safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Autologous oral mucosal epithelium for treating rare diseases becomes approved therapy in Japan

The Japanese regulatory authority has approved cultured oral mucosal epithelium as a regenerative medicine product for rare diseases including corneal epithelial disease. Click to read more...

7. Cell communication in muscle regeneration studied.

Muscle regeneration occurs by paracrine signaling interactions of muscle stem cells (MuSCs) and through ligand-receptor interaction analysis, over 100 candidate regeneration-associated paracrine communication pairs between MuSCs and non-myogenic cells have been studied. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Second patient cured of HIV after stem cell transplant

A London patient with HIV underwent allogeneic stem-cell transplantation with cells that had the mutation in the gene CCR5 (CCR5Δ32/Δ32) and remission was reported at 18 months after analytical treatment interruption (ATI). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. New source of progenitors for bone formation identified

A novel stromal lineage‐restricted bone progenitor cell that is associated with transcortical vessels of long bones has been discovered which has the ability to migrate out of cortical bone channels, expand, and differentiate into osteoblasts contributing to new bone formation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Inhalation therapy using stem cells' secreted factors for lung fibrosis

Inhalation treatment of Lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) has exhibited therapeutic potential for lung regeneration in two experimental models of pulmonary fibrosis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Evolution is not always a one sided one increasing specialization and is reversible according to a new study on turtle-ant soldiers wherein their head shapes have not been evolutionary shaped to a particular form but rather depends on the type of tunnel the species in question occupies.
 -Source: ScienceDaily, 9 March 2020 and Proceedings of the National Academy of Sciences, 2020; 201913750

2. The community where you live determines your longevity says a research wherein communities with more fast food restaurants, a larger share of extraction industry-based jobs, or higher population density have shorter life expectancies.     
-Source: ScienceDaily, 10 March 2020 and Social Science & Medicine, 2020; 246: 112759

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