CURRENT STEM CELL NEWS

1. Study reveals role of new bone stem cells in bone healing

Researchers have reported in animal models, postnatal periosteal stem cells (P-SSCs) expressing specific markers which they state to be functionally distinct stem cell subset responsible for lifelong generation of periosteal osteoblasts. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Gene activation can largely expand blood stem cell in lab

Expressing a gene called MLLT3 in culture enabled more than 12-fold expansion of transplantable hematopoietic stem. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. iPS helps create lab stem cell model for organ scarring

iPSC-derived cells have helped create a model for inflammation driven progressive fibrosis in vitro and this model served as a phenotypic drug screen resulting in identifying an anti-fibrotic molecule. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Immune effect underlies stem cell benefit in cardiac disease

A study has shown that cell therapy improved heart function through an acute sterile immune response characterized by the induction of specific macrophages Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Gene controlling stem cell network in plants deciphered

In the root of plant called Arabidopsis, a stem-cell-ubiquitous gene, TESMIN-LIKE CXC2 (TCX2) has been found to orchestrate stem cell division by regulating stem cell-type specific networks. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Machine learning predicts stem cell growth in vitro

Computational modeling, machine learning, and mathematical pattern optimization has been used to predict how pluripotent stem cells organize themselves during in vitro culture and this also helped in optimizing the process. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Transcription factors determine stem cell identity by changing chromatin state

Two transcription factors, Eomes and Brachyury have been found to control the exit of embryonic stem cells from pluripotency and their decision to segregate to form cells of specific germ-layer by changing the chromatin state. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Cancer rainbow mouse created to visualize oncogene mutations

A cancer rainbow mouse has been created by tagging colon cancer mutations that cause the stem cells to glow for visualizing the functional genomics of oncogenic clonal expansion. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. HBO1 maintains leukaemia stem cells

While various epigenetic therapies aimed at treating Acute Myeloid leukemia have shown only modest efficacy due to inability to effectively eradicate leukaemia stem cells (LSCs), researchers have now found that the gene called HBO1 maintains the LSCs and have developed a highly potent small-molecule inhibitor of HBO1. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Gene editing equips cardiac stem cells to evade immune attach after transplantation

By using CRISPR-Cas9 to genetically remove a gene called Beta-2-Microglobulin from cardiac stem cells, researchers have been able to prove that these cells when transplanted can evade attack by immune cells to avoid being rejected. Click to read more...

 

Really???

1. Temporary sight deprivation can actually help hearing-impaired people adapt to cochlear implants and hearing aids, according to a study which found that a week in the dark rewires brain cell networks and changes hearing sensitivity in adult mice
 -Source: ScienceDaily, 4 December 2019 and eNeuro, 2019; ENEURO.0269-19.2019

2. Little exercise during developmental period may actually extend lifespan. Oxidative stress experienced early in life has been shown to extend lifespan in C. elegans. Thus, in humans too, exercise and calorie restriction when young which can lead to Oxidative stress may actually help them live longer, if these results are extrapolated.     
-Source: ScienceDaily, 4 December 2019 and Nature, 2019; DOI: 10.1038/s41586-019-1814-y

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