CURRENT STEM CELL NEWS

1. Novel method to discriminate cancer cells and stem cells

A single-cell multi-omic approach called MutaSeq has been used to distinguish cancer stem cells, mature cancer cells and normal stem cells based on their gene expression. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. New protein part of triad regulating muscle cell formation from stem cells

Development of stem cells into muscle cells which was earlier thought to be regulated with the help of only two proteins Hes1 and MyoD, has now been shown to rely on another protein as well called Delta-like1. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Allogeneic stem cells genetically engineered with bi-functional molecule for targeting brain metastatic breast cancers

Stem cells have been genetically engineered with a bi-functional molecule, EvDRL, to target excess of epidermal growth factor receptor (EGFR) and death receptors 4 and 5 (DR4/5) simultaneously and induce cell death in Basal-like breast cancer (BLBC) which show brain metastatic (BM) capability. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Restoring youth in blood stem cells

Decrease in a cell housekeeping process known as chaperone-mediated autophagy (CMA) with aging leads to blood stem cell decline with age. A study has shown that pharmacological activation of CMA can restore the functionality of the old mouse and human hematopoietic stem cells (HSCs). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Cartilage cell therapy boosted using HA enhancing scaffold

A 3D platform has been shown to help grow in vitro, the ideal type of cartilage cells including chondroprogenitors and mesenchymal stem cells enriched with hyaluronic acid. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Proper ribosome assembly crucial for stem cell regeneration - highlights study

A study has shown that a protein coding gene called E3 ubiquitin ligase HectD1 plays a key role in regulating blood stem cell function through proper ribosome assembly and protein translation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Balancing Nuclear proteins help reverse age-related decline of neural cell regeneration

By balancing the levels of nuclear lamina protein LB1 and SUN1 in aged neural stem cells (NSCs) researchers have been able to restores the strength of the endoplasmic reticulum diffusion barrier which resulted in enhanced stem cell activity of aged NSCs. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Blastocyst complementation used to generate gametes in rats

Blastocyst complementation is a method in which when stem cells are transplanted into the blastocyst obtained from animals that cannot make a certain organ, the stem cells compensate the missing organ. Now researchers have used xenogeneic mouse stem cells Blastocyst complementation to generate mouse gametes in the body of rats. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Phase II trial of MSCs in spinal cord injury show positive outcome

In a phase 2 study of intravenous infusion of autologous mesenchymal stem cells (MSCs) cultured in auto-serum into human patients with spinal cord injury (SCI) has resulted in functional improvements at six months in all the patients.. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Nutritional supplement acts as vaccine adjuvant for COVID-19 by stimulating all arms of immunity

A beta glucan food supplement has been shown to have potentials to act through all the four pathways of immune system viz., Mucosal immunity, Adaptive immunity, Innate immunity and Trained immunity, thus serving as a potential immune-modulating vaccine adjuvant for COVID-19. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know the influence of father's environment such as diet is transmitted by the sperm to the embryo through a non-DNA based epigenetic process, associated with histone proteins?
 -Source: ScienceDaily, 16 March 2021 and Developmental Cell, 2021 DOI: 10.1016/j.devcel.2021.01.01

2. Some people are simply not scared of ghosts. This could be due to their brain's inability to visualise mental images or aphantasia, say researchers.    
-Source: ScienceDaily, 10 March 2021 and Proceedings of the Royal Society B: Biological Sciences, 2021; 288 (1946): 20210267 DOI: 10.1098/rspb.2021.0267

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