CURRENT STEM CELL NEWS

1. Cell membrane engineering for efficient stem cell delivery to heart

A new cell membrane modification methodology utilizing the tissue homing properties of the infectious bacteria Streptococcus gordonii has helped improve retention and homing of stem cells delivered either intracardially or intravenously to the myocardium. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Vaccine reduces shingles occurrence after stem cell transplantation

A 2-dose course of recombinant zoster vaccine has reduced the incidence of herpes zoster in autologous stem cell transplant recipients. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. 3D stem cell model of epiblast helps study embryonic axial symmetry break

An in vitro three-dimensional model of human epiblast has been created by researchers using human embryonic stem cells and this model will serve as an assay for the molecular events underlying human axial symmetry breaking. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Light and chemical based activation of stem cells inside body

Selective excitation of transplanted iPS cell-derived neural progenitor cells using Optochemogenetics has been found to recapitulate an activity-enriched microenvironment that confers regenerative benefits in the treatment of stroke. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Engineered stem cells to target and kill cancer bone metastases

Mesenchymal stem cells engineered using mRNA have been used to target both the cancer cells and the niche in bone metastasis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. T cells infiltrate old neural niches in brain – study reveals

Analysis of 14,685 single-cell transcriptomes has revealed that there is an infiltration of T cells in old neurogenic niches and this finding opens potential avenues to counteract age-related decline in brain function. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Artificial signalling centre to control stem cells

A microfluidic approach has been used to spatiotemporally control human pluripotent stem cell (hPSC) colonies using morphogen gradients generated from artificial signalling centres. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. New class of anti-cancer small molecules against cancer stem cells discovered

Scientists investigating improvements to a commonly used chemotherapy drug have discovered a new class of small molecule anticancer agents which show enhanced toxicity towards mesenchymal breast cancer populations with cancer stem cell properties. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. E-cigarettes damage brain stem cells – says study

Electronic cigarettes have been identified to produce a stress-induced mitochondrial hyperfusion in neural stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Specific Metabolic enzyme characterize dormant brain cancer stem cells

An enzyme of energy metabolism, Glycerol-3-phosphate dehydrogenase 1 (GPD1) has been found to be responsible for the "stemness" of dormant brain tumor stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Researchers have now postulated that some of the deadliest neurological diseases like MS, ALS and schizophrenia must have been actually encoded in our genome by the remnants of human endogenous retroviruses or HERVs in our DNA.
 -Source: ScienceDaily, 11 July 2019 and Frontiers in Genetics, 2019

2. Did you know parental environment can have a profound impact on future generations? Yes a new study has shown how environmental stressors put on fruit flies (Drosophilia melanogaster) can influence the phenotypes of their offspring.     
-Source: ScienceDaily, 9 July 2019 and eLife, 2019; 8

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