CURRENT STEM CELL NEWS

1. Second patient with long term HIV remission by stem cell transplant reported

The first person with HIV who was treated for cancer using a stem-cell transplant subsequently went into viral remission was the Berlin patient. Now, a second patient has achieved HIV remission after stem cell transplant for at least 18 months following a less aggressive and toxic approach. Click to read more...

2. iPS derived NK cell immunotherapy enters clinical trial phase

The US FDA has approved a clinical trial that is going to investigate NK cells derived from induced pluripotent stem cells both alone and in combination with checkpoint inhibitors in patients with advanced solid tumors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. MSCs obtained from iPS cells acquire rejuvenation signature irrespective of donor age

A study has shown that Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) irrespective of donor age and cell source acquire a rejuvenation gene signature thus helping to overcome the drawbacks associated with use of adult MSCs. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Mere injection of an enzyme helps corneal stem cell regeneration in situ

By injecting collagenase into the burnt surface of cornea scientists have found that it is possible to restores the tissue's mechanical properties and ability to support limbal epithelial stem cell (LESC) regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Study uncovers protein to keep skin youthful

Skin cells keep regenerating by a process wherein the new adult cell derived from the basal layer of epidermis start its journey through the epidermis. But with aging or due to exposure to UV light or other toxins the original stem cell in the basal layer also gets pushed off due to loss of a protein called collagen 17. A new study has shown that if the level of collagen 17 is maintained, the skin organ ageing process is rescued. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Rapid technique allows Ultra-multiplexed analysis of single-cell dynamics

An ultra-multiplexed microfluidic system has been developed for high-throughput single-cell analysis which has allowed researchers to study hidden aspects of cellular dynamics. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Combined Stem Cell and Gene Therapy shows improvement in Huntington's disease

Genetically modified neural progenitor cells (NPCs) grafted into mice models with Huntington's disease (HD) showed significant improvement in motor functions. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. MSCs show positive outcome in patients with knee arthritis

Significant improvements in the pain levels and quality of life has been reported in patients with knee osteoarthritis injected with autologous mesenchymal stromal cells (MSCs). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Founder stem cells discovered

Researchers have made an astonishing discovery of a unique subset of cells within human stem cells that appear to signal and control how the surrounding cells will develop and grow. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Cells shape their own fate – Hydrogel study reveals

Using a novel bio-orthogonal labelling technique scientists have studied the impact of early protein deposition on cell behaviour within hydrogels and found that cells essentially determined their own function by shaping their environment through proteins. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Wisdom says smiling makes you happier. Now a scientific study which analysed data from 138 studies testing more than 11,000 participants from all around the world has proved that facial expressions indeed have an emotional impact on feelings.
 -Source: ScienceDaily, 12 April 2019 and Psychological Bulletin, 2019

2. Contrary to conventional theories that life started in oceans, researchers have now postulated that it is shallow bodies of water, on the order of 10 centimetres deep, that could have held high concentrations of nitrogen which gave rise to life.     
-Source: ScienceDaily, 12 April 2019 and Geochemistry, Geophysics, Geosystems, 2019;

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