Table 3. Mean Primary Outcome Scores for BMAC and HA Groups at baseline, 3 months, 6 months and 12 months following treatment

Outcome
Measure

Group

Time

n

Mean (SD)

Mean DifferenceA (95% CI)

p-valueA

Mean DifferenceB (95% CI)

p-valueB

KOOS
Pain

BMAC

Baseline

17

60.82 (15.05)

-

-

-2.51 (-13.79, 8.77)

0.663

 

3 mo

15

77.53 (17.80)

16.71 (6.71, 26.71)

0.001

5.78 (-5.78, 17.33)

0.327

 

6 mo

14

80.86 (15.68)

20.03 (10.71, 29.36)

<0.001

7.51 (-5.71, 20.73)

0.265

 

12 mo

13

84.31 (13.54)

23.48 (14.85, 32.12)

<0.001

10.82 (-2.43, 24.06)

0.109

 

HA

Baseline

15

63.33 (17.72)

-

-

 

 

 

 

3 mo

15

74.27 (15.28)

10.93 (5.15, 16.71)

<0.001

 

 

 

 

6 mo

14

75.86 (14.23)

12.52 (3.16, 21.89)

0.009

 

 

 

 

12 mo

14

76.00 (16.4)

12.67 (2.62, 22.71)

0.013

 

 

KOOS
Symptoms  

BMAC

Baseline

17

66.53 (16.01)

-

-

-2.27 (-13.09, 8.55)

0.681

 

3 mo

15

83.93 (13.42)

14.00 (4.38, 23.63)

0.004

3.54 (-8.35, 15.43)

0.560

 

6 mo

14

80.79 (11.27)

14.26 (4.70, 23.81)

0.003

1.84 (-9.98, 13.66)

0.760

 

12 mo

13

84.54 (9.05)

18.01 (10.29, 25.72)

<0.001

9.81 (-1.69, 21.31)

0.095

 

HA

Baseline

15

63.80 (15.69)

-

-

 

 

 

 

3 mo

15

79.27 (15.41)

10.47 (3.48, 17.45)

0.003

 

 

 

 

6 mo

14

81.21 (13.34)

12.41 (5.45, 19.37)

<0.001

 

 

 

 

12 mo

14

77.00 (16.23)

8.20 (0.33, 16.73)

0.06

 

 

KOOS ADL

BMAC

Baseline

17

68.59 (17.98)

--

-

-1.55 (-13.95,10.86)

0.807

 

3 mo

15

83.93 (13.42)

15.35 (5.10, 25.59)

0.003

2.88 (-9.25, 15.01)

0.642

 

6 mo

14

86.71 (11.92)

18.13 (9.00, 27.25)

<0.001

3.19 (-9.60, 15.98)

0.625

 

12 mo

13

87.69 (13.25)

19.10 (9.52, 28.68)

<0.001

7.24 (-6.48, 20.95)

0.301

 

HA

Baseline

15

70.13 (18.34)

-

-

 

 

 

 

3 mo

15

82.6 (15.90)

12.47 (5.97, 18.96)

<0.001

 

 

 

 

6 mo

14

85.07 (12.54)

14.94 (5.98, 23.90)

0.001

 

 

 

 

12 mo

14

82.00 (16.84)

11.87 (2.05, 21.68)

0.018

 

 

KOOS
Sport

BMAC

Baseline

17

31.47 (23.57)

-

-

-8.20 (-23.59, 7.20)

0.297

 

3 mo

15

60.93 (27.25)

29.46 (13.02, 45.91)

<0.001

-0.60 (-20.59, 9.39)

0.953

 

6 mo

14

66.36 (26.27)

34.89 (19.90, 49.88)

<0.001

3.27 (-18.08, 24.62)

0.764

 

12 mo

13

70.54 (28.66)

39.07 (22.00, 56.13)

<0.001

13.02 (-8.36, 34.40)

0.233

 

HA

Baseline

15

39.67 (21.59)

-

-

 

 

 

 

3 mo

15

69.73 (25.19)

30.07 (18.71, 41.43)

<0.001

 

 

 

 

6 mo

14

71.29 (22.22)

31.62 (16.41, 46.82)

<0.001

 

 

 

 

12 mo

14

65.71 (24.87)

26.05 (13.16, 38.93)

<0.001

 

 

KOOS
QOL

BMAC

Baseline

17

36.18 (18.50)

-

-

-2.29 (-14.03, 9.45)

0.702

 

3 mo

15

57.20 (21.34)

21.02 (9.03, 33.01)

0.001

-0.24 (-15.96, 5.48)

0.976

 

6 mo

14

61.14 (18.83)

24.97 (14.51, 35.42)

<0.001

0.79 (-16.04, 17.62)

0.927

 

12 mo

13

63.62 (18.17)

27.44 (17.61, 37.27)

<0.001

5.98 (-10.43, 22.38)

0.475

 

HA

Baseline

15

38.47 (15.94)

-

-

 

 

 

 

3 mo

15

59.73 (19.89)

21.27 (11.10, 31.43)

<0.001

 

 

 

 

6 mo

14

62.64 (17.10)

24.18 (10.99, 37.36)

<0.001

 

 

 

 

12 mo

14

59.92 (17.83)

21.46 (8.33, 34.60)

0.001