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Proceedings of the Just Beyond Medicine (JBM)Oration-2018

Stem cells for regenerative medicine and anti-aging
Hescheler J1

Author Names in full:Jurgen Hescheler

1Dept. of Neurophysiology, University of Cologne, Germany

Citation: Hescheler J. Stem cells for regenerative medicine and anti-aging. Proceedings of the Just Beyond Medicine (JBM) Oration-2019; J Stem Cells Regen Med 2019; Dec;15(2):53

There is no doubt that work on stem cells will be the most promising approach for the medicine of the 21st century and probably revolutionize the therapy of many diseases including cardiac infarction and failure, diabetes, Parkinson’s disease, spinal cord lesion etc.

It is our aim to provide a fundamental basis to the development of new medical treatments. Stem cell research is a broad field which requires nearly all techniques of modern life science such as genetics, cell biology, physiology, biochemistry, histology, etc. - but it also requires the input of experimental surgery and bioengineering technologies.

Induced pluripotent stem (iPS) cells represent the most promising approach for future stem cell-based tissue repair in regenerative medicine. iPS cells are functionally highly similar to embryonic stem (ES) cells, but have in addition the advantage of being ethically non-controversial, and are obtainable from readily accessible autologous sources. However, although proof of principle for the therapeutic use of iPS cells in cardiac diseases has been shown both at the laboratory scale and in mouse models, the methods used today for generation, cultivation, differentiation and selection still have to be translated for their later clinical usage.

This presentation will give an overview on our recent research work on human embryonic and iPS cells. Starting from our basic investigations on the physiological properties of cardiomyocytes developed from pluripotent stem cells we have established in vitro and in vivo transplantation models enabling us to systematically investigate and optimize the physiological integration and regeneration of the diseased tissue. Our focus is the cardiac infarction model.


The Just Beyond Medicine (JBM) Oration-2018 was sponsored by JBM Inc., Japan

The lecture was delivered in the Just Beyond Medicine (JBM) Oration - 2019 session of NCRM NICHE ( which is a day of commemorative events to celebrate the inaugural Anniversary of Nichi-In Centre for Regenerative Medicine, conducted every year since 2006 in the month of October. NCRM NICHE provides a platform that augments the interaction of scientists and clinicians. It enables them to exchange ideas in order to arrive at synergies while working towards a common goal of discovering clinically applicable solutions for diseases without a definitive treatment to yield relief to numerous patients. Conducted in India till 2016, it has been conducted in Japan from 2017 onwards. NCRM NICHE has two components: 1. Active Knowledge Gaining (AKG) events which refer to any knowledge gaining activity in which the participant plays an active role before and during the event instead of being a passive listener to a lecture by a speaker or a conversation among third parties. AKG events of NCRM NICHE include a. Fujio Cup Quiz (FCQ); b. Oral Presentation session and c. Tour to Premier Institutes and Inter Disciplinary Conclave (IDC); 2. Passive Knowledge Gaining (PKG) events which refer to an event, where there is no mandatory preparation by the participants before the event. During the event, they have to merely be a passive listener to others either delivering a lecture or interacting among third parties. PKG events of NCRM NICHE include a. Lectures & Orations and b. Inter-Disciplinary Interactions and Solutions (IIDIAS) Session. NCRM NICHE 2019 was conducted at the Shibaura Institute of Technology, Tokyo, Japan from 14 ~ 16 October 2019.