CURRENT STEM CELL NEWS

1. Stem cell study shows how leukaemia stem cells react to a new ground breaking treatment

A research has shown how scientists have been able to grow and maintain leukaemia stem cells in a laboratory dish and how these stem cells react to BET-inhibitors, a novel therapeutic strategy currently under clinical trials. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Scientists create mini-brain in lab made up of the stem cells from rare neurological disorder

Mini-brain made up of the stem cells derived from the patient with a rare neurological disorder known as MECP2 duplication syndrome has been developed in the lab and a drug candidate that suppresses the genetic alteration responsible for the disorder has also been identified in this research. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Pancreatic cancer stem cells (PancSCs)'s addiction to oxygen-based metabolism makes them vulnerable to diabetic drug

It has been found that pancreatic cancer stem cells (PancSCs) can use a more efficient form of metabolism known as oxidative phosphorylation (OXPHOS) and this metabolism can be targeted with the anti-diabetic drug, metformin. The study also showed that it is possible to force even those PancSCs which are more flexible in their metabolism and can thus escape the drug leading to recurrence of pancreatic cancer. Click to read more...

4. A stem cell suicide switch developed to safeguard iPSC-mediated cell therapy

Rejuvenated T Cells derived from Induced Pluripotent Stem Cells are effective against EBV-induced tumors. In order to make this potential therapeutic strategy more safer, scientists have created an Inducible caspase-9 (iC9)-based suicide switch for these cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Key molecular mechanism underlying aggressive behaviour in hard-to-treat breast cancer identified

A single master gene Sox10 has been shown to be specifically expressed in breast mammary cells exhibiting the highest levels of stem cell activity. Also the increased expression of Sox10 has been found in stem- and mesenchymal-like breast cancers making the gene a potential therapeutic target. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Unique stem cell population in brain mapped

Researchers have mapped the genetic signature of a unique group of stem cells in the human brain and it has been suggested that that these stem cells might be responsible to generate most of the neurons in the human's cerebral cortex. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Pluripotent stem cell based in vitro neural constructs to serve as drug testing models

Neural tissue constructs with blood vessels and microglia have been developed from human pluripotent stem cells and these organoids will serve to be highly useful in predictive toxicology . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Single cell analysis of breast cancer metastatic cells reveals distinct stem-like gene signatures

Individual metastatic cells from human breast cancer tumors have been studied and it has been discovered that the genetic programs of these cells were different from the primary tumors from which they originated. Also these cells contained genes characteristic of mammary stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Deep imaging of bone marrow uncovers specific location of stem cells

A bone marrow clearing technique and use of green fluorescent protein (GFP) has helped to identify that most of the stem cells in the bone marrow reside in the perisinusoidal niches. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Nano-membranes for Transfer-Printable Stem Cell-Derived Cardiac Sheets

Nanothin membranes have been shown to encourage co-culture of stem cells and have been shown to provide an easy way to separate the grown sheets of cardiomyogenically differentiated cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware about Gene drive? It refers to the genetic tool which contains what are known as selfish genetic elements and this tool can be used to alter the genetic make-up of an entire population according to the need. For eg. Gene drive elements can help in making mosquitoes less dangerous .     
 - Source: Nature. 2011 May 12; 473(7346): 212–215 and Wikipedia

2. Did you know about Nano- Brain? It is a conceptual nano device made up of a molecular assembly with parallel computational abilities developed based on the principles of the processing machinery of the human brain. A nano-brain made of 17 identical molecules of Duroquinone with ability to execute 16 instructions at a time has been reported.    
                                                   -Source:Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3668-72 and Wikipedia

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