CURRENT STEM CELL NEWS

1. Lab engineered Diaphragm successfully transplanted in rats

Researchers have used decellularized rat diaphragms and a novel bioreactor to create lab engineered diaphragms using stem cells which were transplanted to rats with positive outcome. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Mathematical models of 3D brain tissue constructs offers vital clues on brain development

An analytical model applied to lab created brain tissue has helped researchers to study oxygen and nutrient delivery to cells, predict cell viability and helped understand a regionalization process that occurs during early brain development. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Planarian stem cell differentiation studied

Two studies have explored the processes that occur when stem cells in planaria differentiate into skin cells. One study explored the key regions in the genome targeted by two enzymes of which one was involved in maintenance of the planarian stem cell population and the other was involved in the process of cilia formation in the skin. The second study showed the step wise process of cells called neoblasts developing into epidermal cells of the planaria's skin. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal | Click here to view the link of the relevant publication in a peer reviewed journal

4. Use of hematopoietic stem cell transplantation (HSCT) in patients with refractory Crohn disease questioned by clinical trial outcome

The results of a clinical trial on HSCT for Crohn disease conducted in 11 European transplant units has shown HSCT does not bring about any in significant improvement in terms of sustained disease remission at l year compared to conventional treatment and also there were significant toxic effects associated with HSCT. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Pluripotent stem cells incorporated into embryo using novel approach

To understand how stem cells would incorporate into the body, scientists have successfully transplanted human pluripotent cells into a mouse embryo using a novel stage-matching approach and the results proved normal growth and development. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Nano-coated cells to treat hair loss

Scientists from China and Canada have employed a layer-by-layer nano-coating with biocompatible materials to coat the dermal papilla cell (DPC) along with fibroblast growth factor-2 (FGF-2)and showed that this strategy can boost the intrinsic therapeutic effect of these cells in treating hair loss. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. World's first clinical trial on neural stem cells for Parkinson's Disease approved

A first of its kind Phase I/IIa clinical trial on human parthenogenetic stem cells-derived neural stem cells (ISC-hpNSC) in patients with Parkinson's disease (PD) has been approved by the regulatory authorities in Australia. Click to read more... | Click here to view the link of the relevant publication

8. CAR T-cells offer promise in malignancies which progressed even after stem cell transplant

A study obtained donor lymphocytes from the original donor of the stem-cell transplant in 20 patients with B-cell malignancies and these cells were genetically modified to express an anti-CD19 chimeric antigen-receptor (CAR). Upon infusion into the patients, there was a rapid response and improvement in eight of the patients. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Erasing cellular memory for faster reprogramming

A study has identified four chromatin regulators which when suppressed can effectively erase the memory of a cell making it more amenable to reprogramming. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Chronic inflammation leads to aberrant cell programming

Chronic inflammation in the eyes of mice can cause corneal stem cells to undergo aberrant reprogramming and turn into skin cells causing the mice to become blind according to a recent report. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware that exercising early in life can increase the bacteria in your gut that are involved in promoting psychological and metabolic health via the gut-brain axis? This early life exercise is suggested because the gut microbiota are more plastic during the early stages of colonization.     
 - Source: : Mika A et al. Immunology and Cell Biology. 2015 and www.sciencedaily.com/releases/2015/12/151229204252.htm

2. Did you know that all humans originally had brown eyes? Variation of the eye colour is due to the difference in the amount of melanin in the iris. It has been identified by a study that all blue eyed humans have a single, common ancestor in whom a genetic mutation occurred 6-10,000 years ago.    
  -Source: Eiberg H et al. Human Genetics 2008 and www.sciencedaily.com/releases/2008/01/080130170343.htm

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