CURRENT STEM CELL NEWS

1. Intestinal stem cells offer new insights into homeostasis and cancer

A metabolic switch from oxidative phosphorylation to glycolysis was thought to be an indication of cancer. However it has been identified that even under normal conditions, intestinal stem cells exposed to higher levels of glucose switch into growth mode with higher rates of glycolysis, with no change in the rates of oxidative phosphorylation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Stem cells in stroke patients' brain may not be dead but actually dormant - says study

A clinical study which used adult stem cells to treat stroke patients has shown that some of those patients regained movement and speech years later thus implying that the stem cells in those patients usually believed to have died actually lie dormant and get activated later to resurrect the circuits. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Novel targeted delivery of cancer stem cells to fight cancer

A novel strategy has been devised to selectively target cancer stem cells (CSCs) to induce downregulation of a transcription factor known as STAT3 which in turn can reduce expression of a series of 'stem-ness genes' in treated tumours. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Blood stem cell populations explored

A study has explored the various resting, proliferating, and differentiating stem cells (HSCs) in the bone marrow and has suggested that short-term (ST)-HSCs control haematopoiesis by paracrine effects acting as an initiator of further differentiation of multipotent progenitors of hematopoietic cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Fat stem cells have a different biological clock - reveals study

Adipocyte precursor cells have been identified to have a circadian clock that functions differently from the ones found in other cells. any disturbance to the clock changes the pace at which the cells turn into mature adipocytes, or fat cells. This discovery could probable throw light on why night-shift workers are at risk for metabolic diseases like diabetes. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Wound microenvironments alter supporting cell fate to help in healing

It has been identified that in peripheral nerves after an injury the wound microenvironment makes the supporting Schwann cells to de-differentiate to become invasive mesenchymal-like cells to promote nerve regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Neural stem cells show promise in Parkinson's disease

Initial results of a Phase 1 trial which used neural stem cells to treat patients with moderate-to-severe Parkinson's disease has shown that the patients are performing better at six months. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Embryonic lung stem cell population isolated

Sox9+ multipotent embryonic lung progenitors have been isolated and expanded long term in 3D culture in vitro. This population is capable of generating cells that can differentiate into both cells of the alveoli and airways which are separately maintained by distinct lineage-restricted stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Mechanism behind inability of pluripotent stem cells harbouring microRNA deficiencies to differentiate, revealed

The process that underlies pluripotent stem cells (PSCs) which are deficient for microRNAs (miRNAs) such as Dgcr8−/− or Dicer−/– not able to differentiate into somatic cells has been found to be due to suppression of p53. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Functional heart patch developed in lab

A "Cardiopatch" platform for 3D culture and maturation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has been developed and the patches grown using this platform have shown functional properties after 5 weeks of differentiation in the lab. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Scientists have found that nightmares are actually due to frustrations in daily life experienced by the individual. This was inferred from two studies on recurring dreams and psychological needs in waking life. The studies identified that "bad" dreams might be "left-overs" of poorly or even unprocessed daily experiences.
 -Source: ScienceDaily, 30 November 2017 and Motivation and Emotion, 201

2. New born babies with higher levels of background stress show greater response to pain according to a new study. Thus, it has been suggested to treat and care for babies in a manner that will minimize both pain and stress.      -Source: ScienceDaily, 30 November 2017. Current Biology, 2017

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