CURRENT STEM CELL NEWS

1. Decellularized husk of plants to serve as scaffolds for tissue engineering

Scientists have used decellularized husks of plants such as parsley, vanilla and orchids to form three-dimensional scaffolds for using them to optimize culture of human stem cells in vitro. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Lung plays crucial role in blood cell production – astonishing discovery

In addition to bone marrow being the primary source of blood cell production, scientists have discovered in mice that lungs play a crucial role in the process by producing half of the blood platelets and also play a role in storing blood-forming stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Adult progenitor cell based stem cell clinical trial for Stroke offers hope

A phase 2, randomised clinical trial of intravenous multipotent adult progenitor cells in young patients with moderately severe acute ischaemic stroke has shown that the cell injections are safe and well tolerated. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. iPS application in Age Related Macular Degeneration; One-year follow-up reported

The 1 year follow up of world's first clinical trial on transplantation of sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) has shown that the transplanted sheet remained intact while best corrected visual acuity had not improved or worsened in the patient. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Study identifies markers for naïve and primed pluripotent stem cells

Researchers have done the comprehensive profiling of cell surface proteins by flow cytometry in naive and primed human pluripotent stem cells (PSC) thereby identifying a robust set of molecular markers to define the human PSC state. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. iPS cell based in vitro model for eating disorder

Anorexia nervosa (AN) a complex eating disorder occurring predominantly in women has been modelled in the lab using induced pluripotent stem cells which has helped researchers to identify a novel gene that appears to contribute to the disease pathophysiology. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Aging in gut stem cells partially reversed

Gut's homeostasis is maintained by intestinal stem cells (ISCs). A study has identified that there is a decline in the regenerative capacity of ISCs upon aging due to decline in canonical Wnt signaling in the ISCs. When this signalling pathway was reactivated in vitro, there was reversal of aging in these cells. Click to read more... | Click here to view the link of the relevant publication

8. iPS cell based lab model fails to capture rare mutations in psychological disorder

Though induced pluripotent stem cells help in modelling various diseases in vitro, it has been found that some heritable but unstable genetic mutations that are passed from parent to affected offspring in psychotic disorders may not be easy to investigate using current human iPS modelling techniques. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. New cell culture platform provides better control of culture conditions

A novel technology platform which consists of integrated microfluidic channels and nanofibers along with high-content single-cell analysis has helped to study the effects of environmental factors on stem cell phenotype in vitro. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Electroacupuncture makes brain release mesenchymal stem cells into circulation for pain relief- says study

A recent study has provided the most comprehensive picture of how electroacupuncture stimulates the brain to release mesenchymal stem cells (MSC) into the systemic circulation which increases anti-inflammatory cytokine production and provide pronounced pain relief. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Hippocampus in the brain which was long believed to be useful mainly in mapping of one's environment, acting as the brain's GPS navigation map has been found to play important roles in cognition also which solves the long standing mystery of how the hippocampus could be associated both with making maps of the external environment and in making new memories. Thus when people visit new places, they don't only make mental maps but also form memories of the location.    
 -Source: ScienceDaily, 30 March 2017 and Nature, 2017; 543 (7647): 719

2. The reason why some brain cancer patients develop resistance to radiation and chemotherapies has been identified due to a protein known as Aktr3 which when prevalent in the brains of these patients activates key DNA repair pathways thereby leading to enhanced DNA repair of the brain cells contributing to treatment resistance.    
-Source: ScienceDaily, 2 March 2015 and Proceedings of the National Academy of Sciences, 2015; 112(11):3421-26

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