CURRENT STEM CELL NEWS

1. Bacteria coated materials for efficient stem cell engineering

A coating of non-pathogenic bacteria which has been genetically engineered to secrete proteins into its surrounding environment has been used to grow human stem cells for more successful differentiation of the human cells to bone.. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Phase II stem cell therapy for ALS started

A phase II clinical trial that employs stem cells engineered to produce signalling molecules that regulate the activity of surrounding cells and also secrete neurotrophic factors (NTF) to treat amyotrophic lateral sclerosis (ALS) has been started in the US. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. New treatment for stroke using silk fibroin encapsulated stem cells

A silk fibroin-based biomaterial has been used to support the survival of intracerebrally implanted mesenchymal stem cells (mSCs) in a model of cortical stroke. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Hydrogel based multicellular tumor spheroids for advanced drug screening

A hydrogel microwell array has been used to generate uniform-sized multicellular tumor spheroids which could serve as a powerful tool for anticancer drug screening applications.Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Japanese scientists create optic cups model for quantitative prediction of embryonic development

A versatile computational model of 3D multicellular dynamics at single-cell resolution has been combined with the 3D culture system of pluripotent stem cell–derived optic-cup organoid for quantitative prediction of morphogenesis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. New cancer treatment may actually boost lung cancer stem cells – suggests study

Epigenetic therapies are novel cancer therapies that target enzymes altering genes in a cell making a cancer less aggressive or less malignant. Researchers a now report that at least one epigenetic therapy that initially looked promising for lung cancer actually boosts cancer stem cells that are believed to drive tumors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Biomimetic citrate-based material for accelerating bone regeneration

A biomimetic citrate-based material has been shown to promote significant improvements in bone regeneration and tissue response in rat femoral-condyle and cranial-defect models. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Molecular mechansims governing T cell identity deciphered

Proteomic analysis has helped in defining the molecular basis of the direct and indirect actions of an essential transcription factor Bcl11b which promotes T cell identity and block alternative potentials. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Laboratory stem cell derived platelets – the future of manufacturing platelets

Human adipose-derived mesenchymal stromal/stem cell line (ASCL) has been used to generate platelets in the lab without using genes or feeder cells no feeder cells, further enhancing the clinical application of this approach. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Location of the DNA mutation is more important for cancer development

A study has shown that the number of mutations in healthy and leukemic blood stem cells does not differ but it is the location of the DNA mutations which is more relevant. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Scientists have found that to predict the future, human brain uses two clocks, one based on memories from past experiences and the other on rhythm, challenging theories that a single brain system handles all our timing needs.
 -Source: ScienceDaily, 20 November 2018 & Proceedings of the National Academy of Sciences, 2018; 201810596

2. Did you know that it is table salt which has been crucial for origin of life on earth? Yes, a new study shows that compounds useful for the synthesis of RNA are produced with the help of sodium chloride - table salt.     
-Source: ScienceDaily, 29 November 2018 and Chemistry Select, 2018; 3 (36): 10169

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