CURRENT STEM CELL NEWS

1. Conditionally reprogrammed cells, explored

In a novel study published in PNAS, researchers have showed the potential of Conditionally Reprogrammed Cells (CRCs) in which these CRCs from cervical epithelium formed cervix like structure and those from tracheal epithelium formed trachea like structure in an air-liquid interface culture system. Further, the gene expression profiles of these cells were different from embryonic stem cells and induced pluripotent stem cells and hence these cells don’t give rise to tumours. Click to read more...

2. Cells from Pigs to treat Parkinson's disease, Clinical trial approved- Gives Hopes for Millions

New Zealand scientists have got the ‘go ahead’ to proceed with a clinical trial that places cells derived from pigs into the brains of patients suffering from Parkinson's disease. This trial will compare the benefits of the pig-cell therapy against deep brain stimulation, the gold standard for Parkinson’s disease. Click to read more...

3. iPSCs are the way forward to help find cure for Orphan genetic diseases

As a boon to patients suffering from orphan genetic diseases like Riley-Day syndrome, John Hopkins researchers have created nerve cells from the skin of a patient with Riley-Day syndrome using the iPSC technology which helped them to study mechanisms behind the disease and to screen potential drugs for that disease.Click to read more...

4. Mesoangioblast Stem cells + Hydrogel cell carrier scaffolds = A success formula for skeletal muscle regeneration

Researchers from Europe have embedded Mesoangioblast (Mab) stem cells into a polyethylene glycol and fibrinogen (PF) hydrogel scaffold and injected these grafts into mice with chronically inflamed and sclerotic muscle regions akin to advanced muscular dystrophy. The results showed that Mabs embedded in scaffolds engrafted better than Mabs injected alone. Click to read more...

5. Novel virus-free approach for direct reprogramming of skin cells to neural precursor cells

Neural precursor cells have been directly created from skin cells earlier using viral vectors but the expansion of these created neural precursor cells have been difficult. In a study, scientists have used non viral methods to create neural precursor cells from fibroblasts and they were also able to create colonies of these induced neural precursor cells. Click to read more...

6. Practical and efficient method creates stem cells made from patient’s own blood cells – A breakthrough

A team of researchers have been able to identify the appropriate type of cell from blood to create Induced Pluripotent Stem Cells (iPSCs) and this breakthrough offers an efficient and practical source for iPSCs generation for clinical application. Click to read more...

7. Study offers insights into the process of embryonic stem cell differentiation

In an article published in Nature Structural & Molecular Biology, a research group led by Dr Adrian Bracken has shown how genes are switched on and off in embryonic stem cells as they differentiate into specialized cells.Click to read more...

8. Stem cells turned young to treat aged hearts

It has been shown in a study by Dr. Radisic and colleagues, that certain aging factors are turned off when stem cells donated from elderly patients were grown in a micro-environment with a combination of growth factors. It has been postulated that these ‘aged cells turned young’ could used to treat heart disease in the elderly by using their own stem cells.Click to read more...

9. Mechanism behind the two key proteins in maintaining cell health revealed

Scripps Research institute scientists have unraveled the mechanism by which two cellular proteins bond together to form the cell organelle called auto-phagosome and this research have implications in identifying ways to maintain cell health and also treating cancer. Click to read more...

10. Therapeutically relevant cardiac progenitor cells created from iPS cells

In a first of its kind approach, scientists have identified markers by which functionally relevant Cardiac Progenitor Cells (CPCs) created from induced pluripotent stem cells can be identified and when these CPCs were injected into mice,, that were capable of engrafting into the heart tissue in the mice. Click to read more..

Really???

1. Did you know that your skin has invisible lines called Blaschko's lines or Lines of Blaschko that are invisible under normal conditions but become apparent in certain skin diseases when they manifest themselves according to these patterns? These lines are believed to trace the migration of embryonic cells.

2. Are you aware of the structure called Spemann-Mangold organizers in embryos? These organizers are the ones which organize the different parts of the embryo and when an organizer is transplanted from one embryo to the another, it will organize or induce secondary embryonic primordia regardless of its location in the second embryo.

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