CURRENT STEM CELL NEWS

1. Transparent Zebrafish and novel imaging help unravel blood stem cells interactions with niche

Using advanced imaging technology and utilizing the transparent nature of the Zebrafish, researchers have visualized how a blood stem cell that buds off from the aorta during development is cuddled by different types of cells in its niche before it travels to colonize the future site of production. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Scientists develop skeletal muscle in lab which can respond to external stimuli

Scientists have placed muscle precursors in a 3D hydrogel scaffold which helped to create muscle fiber bundles known as "myobundles." Further, these myobundles contracted in response to electrical pulses which has not been reported earlier in lab grown muscle. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. BPA and estrogens used in birth control may affect sperm producing stem cells – reports study

Exposure to Bisphenol-A (BPA) and estrogens used in birth control or present as water contaminants during development affects the sperm producing stem cells and thus may hamper sperm production later in life, according to a new study in mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Novel Stem cell population capable of generating both bone and cartilage discovered in bone marrow using protein marker

With the help of a protein marker, scientists have identified a novel stem cell population known as osteochondroreticular (OCR) stem cells in the bone marrow of mice which are capable of giving rise to both bone and cartilage. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Blood stem cell transplant for Multiple Sclerosis (MS) can help reverse disability – shows study

The first clinical trial on blood stem cell transplant for multiple sclerosis (MS) has shown positive outcome. Two years post-transplant there was marked improvement in disability in half of the patients and in the patients who were followed up for four years, more than 80% were relapse free. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Role of cell-cycle kinase CDK6 in activation of stem cells responsible for leukemia identified

Scientists have identified that a protein called cell-cycle kinase CDK6 regulates the blood stem cells by inhibiting the transcription factor Egr1 and that CDk6 is responsible for activation of the blood stem cells that lead to development of leukemia Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Chemotherapy drug and Nanodiamonds- an effective combo against resistant cancer stem cells

When the chemotherapy drug Epirubicin was attached to nanodiamonds, this drug delivery complex was capable of killing both normal cancer cells and chemoresistant cancer stem cells. It was also able to prevent secondary tumour formation in liver cancer xenograft models. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Self-organizing Cerebellar tissue grown using pluripotent stem cells in the lab

RIKEN researchers have sequentially applied several signaling molecules to induce three-dimensional cultures of human embryonic stem cells to differentiate into neurons that were then able to self-organize into a multi-layered structure resembling a developing cerebellum. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Pluripotent stem cells used to generate cells with ability to initiate hair growth– Hopes to cure baldness

In a novel approach, human pluripotent stem cells have been used to create neural crest cells that were then coaxed to form dermal papillae cells. These dermal papillae cells when transplanted into hairless mice were able to induce hair growth. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Antibiotics can help treat cancer - says study

Antibiotics might prove a novel therapeutic strategy to treat cancer, as per a new study which has demonstrated the efficacy of antibiotics against cancer cell lines. The antibiotics target the mitochondria of cancer cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware as to in which parts of plants are their stem cells located? Stem cells of plants are located in a region called meristem. Another interesting feature about these stem cells in plants is that they never undergo the process of aging and they remain totipotent enabling them to regenerate any part of the plant throughout their lifetime.- Source: Wikipedia

2. Did you know that alcohol consumption may permanently damage the DNA of blood stem cells leading to bone marrow failure and blood cancers? This was identified by scientists based on their study in mice. This is particularly important in Asian individuals who lack the enzyme ALDH2 (which eliminates acetaldehyde, toxic by-product of alcohol) causing them to suffer from the Asian flush syndrome (AFS). AFS patients whose blood stem cells' DNA might be permanently damaged by alcohol may be at high risk of developing blood cancers and bone marrow failures.     - Source: https://www.cellmedicine.com/blood-stem-cells-permanently-damaged-by-alcohol

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