CURRENT STEM CELL NEWS

1. Cells lining the blood vessels successfully created from human induced pluripotent stem cells (iPSCs)

In a first of its kind study, Harvard stem cell researchers have successfully grown vascular endothelial cells that line the blood vessels from human induced pluripotent stem cells (iPSCs) employing biomechanical cues. Click to read more...

2. Fetal Dermal cells: An ideal source of cells for therapy, says study

Multipotent fetal dermal cells (MFDCs) which have higher proliferation and differentiation potential than adult dermal cells have been isolated and analyzed by a group of researchers who have identified that these MFDCs will be an ideal source for cell therapy due to their unique properties. Click to read more...

3. Protein that sets off a cascade of reprogramming of the cells of the embryo explored

As a possible answer to why proteins like the Oct4 are capable of converting adult cell to pluripotent stem cells, researchers have discovered that Pou5f1 protein, a counterpart of Oct4, helps awakening the genes after the resting period following fertilization in Zebrafish embryo and this gives rise to a cascade of gene products that induce the embryonic cells to form various cells and organs.Click to read more...

4. Direct reprogramming of skin cells into beating heart cells improvised

Though skin fibroblasts have been earlier reprogrammed to heart cells earlier, a team led by Dr. Srivastava have now improvised the process using a five gene cocktail which helped in successful conversion of human fibroblasts to heart –like-cells in vitro and nearly 20% of the reprogrammed cells were capable of transmitting electrical signals. Click to read more...

5. Fetal Stem cells help to improve cognition in lab animals with radiation induced cognitive impairments

Radiotherapy for brain cancer often results in cognitive impairments. Now it has been demonstrated in lab animals which had cognitive defects due to induced cranial irradiation that intra-hippocampal transplantation of fetal-derived human neural stem cells leads to improvements in cognition in these animals. Click to read more...

6. Interfering with the function of a specific gene helps stem cell renewal

It has been discovered that interfering with the function of a gene called GATA3 helps increase rate of blood stem cell renewal and thus helps to create large number of these stem cells which can be used for bone marrow transplantation or gene therapy. Click to read more...

7. Biphasic Electrical stimulation (BES) may help prevent apoptosis of neural precursor cells – Novel strategy to improve stem cell transplantation in spinal cord injury

In a study published in Experimental Biology and Medicine, it has been reported that using a non-chemical procedure called Biphasic Electrical stimulation (BES), a team of scientists have been able to enhance cell survival and prevent apoptosis of olfactory bulb neural precursor cells and this in the future will be useful for cell therapy in spinal cord injury. Click to read more...

8. Exosomes created using stem cells promote functional recovery after stroke in rats

Injecting exosomes released by mesechymal stromal cells into lab rats with experimentally induced stroke has helped in remodeling of the affected brain and also helped in improving the neurological function, according to a recent study. Click to read more...

9. Engineered helper cells with ability to release greater-than-normal amounts of growth factor may aid to optimize stem cell survival after transplantation –proves study

Researchers have created 'Engineered helper cells' using human and mouse cells with ability to make greater-than-normal amounts of the basic fibroblast growth factor (bFGF) and these engineered helper cells when injected into the body of mice along with stem cells helped to improve the survival of the stem cells. Click to read more...

10. Bone-marrow-derived mesenchymal stem cells (BSCs) attenuate cognitive defects in rat model of stroke

A study has reported that intracerebral injection of bone-marrow-derived mesenchymal stem cells (BSCs) has helped to reduce the cognitive deficits in a rat model of stroke suggesting that these stem cells can be a potential therapeutic option for stroke. Click to read more..

Really???

1. Do you know what a Zeitgeber is? Zeitgeber is any external or environmental cue which synchronizes an organism's internal biological rythym to that of the 24-hour light/dark cycle and the 12 month cycle. Examples of zeitgebers include Light, Temperature, Social interactions etc. An example of our circadian rythym or our biological clock being affected by zeitgebers is the Jetlag in which traveling to another time zone affects our sleep-wake cycles, appetite etc.

2. Are you aware that Drosophila melanogaster, the most popular model organism used in scientific experimentation was first employed for research by W.E. Castle in 1901? However it was the work by Thomas Hunt Morgan from 1906 using D. melanogaster to study genetic heredity, winning him the Nobel Prize, which shot this humble fruit fly to popularity.

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