CURRENT STEM CELL NEWS

1. Bone marrow stem cells to boost fracture repair in diabetics

Human bone marrow stem cells derived from a non-diabetic donor when transplanted to a bone fracture in a pre-clinical study has helped in healing of the bone fracture more efficiently compared to the group which did not receive stem cells. Click to read more...

2. Origin of lymphatic vessels uncovered and lymphatic cells grown in lab for the first time

With the origins of the lymphatic system debated earlier, a new study has thrown light on this by identifying that lymphatic precursors arise from cells known as angioblasts in a venous niche. This study, a first of its kind has also identified a factor which promotes the angioblast to lymphatic transition. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Complex signaling interactions between Haemocytes and stem cells in Drosophila intestine explored

Researchers have shown that intestinal stem cells (ISCs) in Drosphila (fruit fly) are regulated by immune cells called macrophage-like haemocytes during the regenerative phase after tissue injury. The complex interactions between these two cells initially promotes tissue proliferation but later shifts the ISCs to a quiescent state preventing pre-cancerous dysplasia Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Neurovascular development in embryo tracked in real time

Researchers have created a new model which allows to track the human embryonic stem cells during the earliest stage of development in real time and their study has shown how autonomic neurons and blood vessels come together to form a neurovascular unit. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Results of clinical trial on stem cells for a rare skin blistering disease show positive outcome

A Phase I/II trial on mesenchymal stem cells for a rare skin blistering condition called recessive dystrophic epidermolysis bullosa (RDEB) has shown positive outcome such as fewer blisters and better wound healing . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Stem cell behaviour during neural regeneration captured by live imaging

Living imaging of neural stem cells in Zebrafish has showed that after an injury these stem cells over time don't divide asymmetrically replenishing the stem cell pool as well as producing neurons but rather divide symmetrically to form only neurons due to which the stem cell population diminishes over time. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Novel stem cell derived devitalized material induces bone formation - reports study

Scientists have extracted bone-producing growth factors from stem cells of embryoid bodies and showed that these factors can give rise to new bone tissues in a manner equivalent to the amount produced in the current standard treatments. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Mode of action of stem Cell niche factor in maintaining plant stem cell pluripotency identified

A study has shown that WOX5 transcription factor, a key regulator of plant stem cell pluripotency exerts its action by moving from the root niche organizer which is a quiescent center into the columella stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Key protein regulating muscle regeneration after injury identified

A protein called Prmt5 has been identified as a key regulator of muscle regeneration. The protein acts by inducing the proliferation of the atellite cells which are muscle stem cells and also it prevents the premature dying of these stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. New sub populations of neural precursor cells discovered in the brain

A novel cell sorting methodology has helped identify that the hippocampus of the mouse brain harbours two distinct sub-populations of cells which are activated by different mechanisms and which produce neurons that differ in gene expression. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that satellite cell which is the muscle stem cell was so named because of its peripheral anatomical location on the surface of the myofibre but beneath its basement membrane?     
 - Source: J Histochem Cytochem. 2011 Dec; 59(12): 1041–1059

2. Are you aware of the RNA world hypothesis? It states that RNA preceded DNA and proteins in evolution, i.e An RNA world existed on earth before modern cells arose; during the RNA world, RNA was capable of storing genetic information and catalyzing the chemical reactions in primitive cells. The proponents of the hypothesis state that DNA could have replaced RNA as a more stable molecule for storing large amounts of genetic information required by complex cells during the process of evolution.      
 - Source: Molecular Biology of the Cell. 4th edition.http://www.ncbi.nlm.nih.gov/books/NBK26876/

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