CURRENT STEM CELL NEWS

1. Biomaterials help identifying metabolite factors driving stem cell differentiation

Supramolecular hydrogels with tunable stiffness have been used to analyse the concentration variation of metabolites during stem cell differentiation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Induced pluripotent stem cells offer hope for Glaucoma

When induced pluripotent stem (iPS) cells differentiated into trabecular meshwork (TM) cells were injected into mice's eyes with Glaucoma, the TM function was restored, intraocular pressure was regulated and neuronal loss was prevented. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. In situ heart regeneration possible using novel mesenchymal precursor –proves clinical trial

In 11 patients during bypass surgery, stem cells were injected into the heart near tissue scars caused by heart attacks and there was 40% reduction in the size of scar. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Mathematical models help predict best stem cell type for heart regeneration

Three original mathematical models have been developed to analyse the interactions of three families of Human mesenchymal stem cell (hMSC) with human cardiomyocytes and has identified that a particular type of hMSC will have increased safety when used in cell delivery cardio therapy. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Nanog reverses stem cell aging

Expression of the stem cell factor NANOG in aged muscle progenitors helped to reverse the cellular aging and restored the cells' ability to generate contractile force. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Role of two key proteins in skin stem cells' function revealed

A study has shown that two proteins Dnmt3a and Dnmt3b are essential to conserve skin stem cells and the study has revealed novel roles of these proteins in disease and tumorigenesis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. 3D hip joint template and stem cell-gene therapy to fight osteoarthritis

A 3-D scaffold template shaped in the form of the ball of a hip joint has been used to grow human adipose-derived stem cells (ASCs) and viral gene delivery has been used to induce this bio-construct to express anti-inflammatory molecules. This study lays foundation for total biological cartilage resurfacing to treat osteoarthritis. Click to read more... | Click here to view the link of the relevant publication

8. Fat tissue forms hideout for cancer stem cells

A study has shown that leukemic stem cells use gonadal fat tissue as a niche to hideout and evade chemotherapy . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. CSF producing brain component regulates brain stem cells – identifies study

Signals secreted from the choroid plexus which is a brain structure that produces the cerebrospinal fluid regulates adult neural stem cells and the stem cells are sensitive to age related changes to this secretome. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Massive bacterial infection exhausts blood stem cells

During infections, a particular molecular signalling mechanism causes the blood stem cells to produce more immune cells. However during massive bacterial infections resulting in sepsis, the same molecular mechanisms malfunction causing exhaustion of the blood stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that the brain is most sensitive to even the tiniest of the physical borders? Yes, in a study which analysed the brain activity of 12 subjects who were shown images of walls, flat surfaces and curbs, even for curbs, the brain reacted almost as vigorously as when the subjects saw a full wall.    
 --Source:Science Daily, 27 July 2016 and Neuropsychologia, 2016; 89: 180

2. Contrary to the reports that some cancers are a result of modernization, researchers have identified a foot bone dated to approximately 1.7 million years ago with definitive evidence of osteosarcoma, a malignant cancer. The foot bone belonged to a hominin or a bipedal human relative according to the analysis.    
  -Source: Science Daily, 28 July 2016 and South African Journal of Science, 2016; Volume 112 (Number 7/8)

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