CURRENT STEM CELL NEWS

1. iPS study reveals defects in cellular differentiation in Schizophrenia

Induced pluripotent stem cells obtained from patients with schizophrenia have been found to carry a genetic mutation which alters the ratio of the different type of nerve cells they produce. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Mitochondria controls intestinal stem cell function

Using a mouse model, it has been demonstrated that loss of a specific mitochondrial protein, HSP60 results in loss of stemness and cell proliferation in intestinal stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Naturally occurring mutation improves reprogramming efficiency

Using mutant cells from patients with a disease called Fibrodysplasia ossificans progressiva (FOP), Dr. Yamanaka and colleagues have identified that the mutation leads to hyper activation of a signalling pathway called BMP-SMAD signalling that leads to increased efficiency of induced pluripotent stem cell (iPSC) generation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Oxidation damages stem cells too

Elevated levels of reactive oxygen species (ROS) have been found to result in DNA damage of the CD34+ hematopoietic stem cells developed from human pluripotent stem cells (hPSCs) and also reduced colony formation and impaired their proliferative capacity. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Vitamin D influences blood stem cells during development, says study

Vitamin D has been shown to affect inflammatory signals which control the formation of blood stem cells in both human and zebrafish . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Dietary approach for depleting blood stem cells before bone marrow transplant

Research has shown that without using chemotherapy or radiation, it is possible to deplete the blood stem cells in mice by using diet deficient in the essential amino acid valine and then these mice can be successfully transplanted with blood stem cells from other mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Entire process of egg formation reconstituted in vitro

Scientists have successfully generated fully potent mature oocytes in culture from mouse embryonic stem cells and from induced pluripotent stem cells. Further they have re-derived pluripotent stem cell lines from these eggs thereby reconstituting the full female germline cycle in the lab. Click to read more... | Click here to view the link of the relevant publication

8. Molecular pathway leading to generation of cells better equipped to fight fungal infections deciphered

Studying the hematopoietic stem and progenitor cells (HSPCs), scientists have identified the molecular mechanism which leads to the generation of macrophages from these HSPCs that are better prepared to deal with the Candida albicans infection. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Immunotherapy and MSCs to treat Scleroderma

Combination of immunotherapy and umbilical cord-derived mesenchymal stem cells (MSCs) could improve treatment in patients with drug-resistant progressive scleroderma, as per a new clinical study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. MRI-guided neural stem cell delivery to brain

Magnetic resonance imaging (MRI) has been employed to effectively target and to track the delivery of the neural stem cell (NSC) pre-labeled with a contrast agent into the putamen of baboons. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Have you wondered why in spite of having two cerebral hemispheres and motor cortices, humans are not equally skilled with both hands? Scientists have explored the reason by studying the response of left- and right-handed participants to cues on targets and have identified that this hand choice is related to hemispheric specialisation for speech and language and may stem from actions which requires use of both hands at the same time. Also, while right-handed people's brain was more primed to use their right hand more, left-handed people did not have this dominant hand attentional bias.    
 --Source:Science Daily, 8 March 2011 and Cortex, 2011; 47 (4): 432

2. The evolution of multicelled animals from single-celled animals may not have been so dramatic as we think and this evolution might have been a very simple step as scientists studying a single-celled amoeba called Capsaspora owczarzaki have found that this amoeba has the same mechanisms to control cell differentiation over time like the ones, higher animals use to control cell development across different tissues. The Capsaspora has the ability to transition from a single amoeba to an aggregated colony of cells to a cystic form during its life cycle.    
                 -Source:ScienceDaily, 13 October 2016 and Developmental Cell, October 2016

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