CURRENT STEM CELL NEWS

1. Oct 4 and Akt- the two key players behind cancer stem cell fate

As a possible mechanism behind the resistance of cancer stem cells to therapies, scientists have discovered that a protein kinase called Akt is deregulated in embryonal carcinoma cells and this in turn causes increased phosphorylation of Oct4 thereby making the cells resistant to cell death signals. Click to read more...

2. Scientists identify method to control type of smooth muscle cell formed in the lab- Major step towards lab engineered blood vessels

John Hopkins researchers have employed growth factors to control whether a smooth muscle should become synthetic smooth muscle cell which will be useful for building small blood vessels or contractile smooth muscle cell to provide structure and stability to blood vessels, in the laboratory. Click to read more...

3. Cadavers – A promising source of mesenchymal stem cells

Mesenchymal stem cells (MSCs) derived from bones of cadaver after five days have been proven to be viable in the laboratory and researchers have been able to produce fat cells, bone cells, cartilage cells from these MSCs.Click to read more...

4. Neural stem cell transplantation improves motor function and respiration in mouse model of amyotrophic lateral sclerosis

In 11 independent studies, it has been observed that injection of neural stem cells in mouse models of amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease, improves motor function and slows progression of disease.Click to read more...

5. Enzyme behind malignant stem cell cloning in chronic myeloid leukemia identified

It has been identified that over-expression of an enzyme ADAR1 causes enhancement of the missplicing of RNA, which results in greater self-renewal and therapeutic resistance of the malignant stem cells in chronic myeloid leukemia. Thus this enzyme will prove to be a potential target for therapy in the future. Click to read more...

6. Highly efficient protocol for producing Cardiac muscle cells from embryonic stem cell lines

Researches from University of California have highlighted a highly efficient protocol for reproducibly generating cultures with nearly 50% of cardiomyocytes (the cardiac muscle cells) from embryonic stem cell lines using a less expensive basal medium. Click to read more...

7. DNA based vehicles to convert cells in urine to stem cells

As a continuation of a previous work that employed retrovirus vectors to reprogram kidney cells in urine to stem cells, a team of researchers from China are now employing DNA based vehicles to minimize the risks associated with use of retroviruses.Click to read more...

8. Stem cell pluripotency and gene expression explored

A new study has offered insights into what are called the ‘enhancers’ of gene expression in embryonic stem cells during development and how these enhancers regulate the maturation of these stem cells into the other types of cells. Click to read more...

9. Different types of Stem cells in the same tissue respond differently to DNA repair gene- says study

Brca1is a DNA repair gene whose mutations are associated with breast and ovarian cancer in humans. It has been demonstrated in a study that when this gene was deleted, hair follicle stem cells in the epidermis degenerate while skin stem cells in the epidermis continue to function. Click to read more...

10. Epigenetic study throws light on crucial molecular pathways in cell development and cancer

It is known that regulatory circuits controlled by molecules called PCLs in stem cells are often misregulated in tumours and researchers are studying the mechanisms behind PRC2 which are the proteins that are recruited by PCL to prevent stem cells from maturation. This has implications in cancer therapeutics also. Click to read more..

Really???

1. Did you know that the gut Microbiome (bacteria in the gut) differs between members of the same family and even between twins? It has been identified that though this gut microbiome differs in terms of organism lineages between twins, there exists a core Microbiome between individual twin pairs which when altered at gene levels lead to states like obesity.

2. Are you aware that the human genome comprises of nearly 8% of genes from Endogenous Retroviruses (ERVs) and these virus derived components are suspected to play a role in auto-immune diseases?

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