CURRENT STEM CELL NEWS

1. iPS cells help to unravel how individual mutations contribute to polygenetic diseases

A series of studies that have analyzed induced pluripotent stem (iPS) cells obtained from large groups of patients have helped to learn how individual mutations contribute to polygenetic diseases. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Clinical trial shows cord blood infusions are safe in children with autism spectrum disorder

A phase I, open-label trial on infusion of autologous umbilical cord blood stem cells in children with autism spectrum disorder (ASD) has shown that the cell injections were safe and there was significant improvements in children's behaviour. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Novel method to preserve sperm stem cells reported

It has been identified that Glycolysis-optimized (GO) culture improves regenerative integrity of sperm stem cells (SSCs) and this technology can be useful when young boys undergo cancer treatment wherein the SSCs can be stored prior and later transplanted back after treatment to produce sperm after puberty. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Pluripotent stem cells with near totipotency developed

A first of its kind study has reported about the derivation of a stable stem cell type which has totipotent-like potential giving rise to both embryonic and extra-embryonic tissue types. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Skeletal muscle cell sheets to treat heart failure feasible – proves clinical trial

A Phase I clinical trial which has tested transplantation of autologous cell–sheets derived from skeletal muscle in patients with severe congestive heart failure has shown promising results wherein the patients showed marked symptomatic improvement. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. iPS cell based in vitro model for eating disorder

Induced pluripotent stem cell-derived neurons from Angelman syndrome (AS) patients, a neurogenetic disorder has helped to understand that there is impaired maturation of resting membrane potential and action potential firing in these neurons. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Macrophages from human iPS cells to study chlamydia infection

Macrophages play a crucial role in killing chlamydia to limit the infection. In a new study scientists have employed CRISPR/Cas9 to genetically edit the human induced pluripotent stem cells and have then observed the ability of macrophages derived from these iPS cells to fight the infection so at to identify the role of crucial genes in fighting the infection. Click to read more...

8. Human midbrain structures created in lab

Scientists have succeeded in converting human skin derived iPS cells into three-dimensional mid brain-like cultures in vitro. These midbrain organoids were able to exhibit neuronal, astroglial and oligodendrocyte differentiation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Functional induced dopamine neurons to treat Parkinson's disease

Human and mouse astrocytes converted into functional induced dopamine neurons (iDANs) were able to correct some aspects of motor behaviour such as gait impairments in a mouse model of Parkinson's disease. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. iPS cells even from twins are not similar in all aspects - suggests study

Human iPS cells from monozygotic twins have been studied in the lab and the results showed that even these iPS cells from twins differed from each other in methylation patterns and a non-genetic biological mechanism has been attributed to the differences. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. A study has identified that animals and humans have evolved to favour one side of the brain because this lateralization helps in processes like perceptual specialization, i.e the more complex a task, the more useful it becomes to have a specialized area to become more proficient and motor specialization, better proficiency in the dexterity of a hand.    
 -Source: ScienceDaily, 19 April 2017. Neuron, April 2017 DOI: 10.1016/j.neuron.2017.02.045

2. Ideas rise from Chaos, proves a recent study. A study has concluded that structure organizes human activities and help us in easy understanding of the world but it kills creativity. The conclusions were derived from a series of experiments in which participants displayed less creativity and cognitive flexibility when they were asked to complete tasks with structured information compared to tasks which did not have any order.    
-Source: ScienceDaily, 22 March 2017 and Organizational Behavior and Human Decision Processes, 2017; 138: 15 DOI: 10.1016/j.obhdp.2016.10.001

Creative Commons License All site content, except where otherwise noted is licensed under a Creative Commons Attribution 3.0 Unported License.