CURRENT STEM CELL NEWS

1. Gene networks behind cooperative and competitive cellular behaviours explored

CResearchers at The Mount Sinai Medical Center while exploring the competition and cooperation among cells, have identified that a network of genes in cells including the tumor suppressor p53 enforces a cooperative state within the cells. If these enforcer genes are mutated then disease occurs due to competitive behaviour among cells. Click to read more...

2. Removing a single molecule improves reprogramming efficiency to almost 100%- says study

A recent study published in the Journal Nature has reported that by removing a single protein, called Mbd3, the conversion rate of adult cells to pluripotency increases to almost 100% and also that all the cells transit to pluripotency on a synchronized schedule. Click to read more...

3. High levels of LDL ("bad") cholesterol promote atherosclerosis by recruiting blood stem cells – reports study

It has been identified that high levels of LDL cholesterol promote atherosclerosis by increasing the production of IL 17 which increases the levels of granulocyte colony stimulating factor (GCSF) and this in turn, stimulates production of hematopoietic stem/progenitor cells (HSPCs).Click to read more...

4. Biochemical signal gradients in 3D cultures – A key to engineer complex tissues

A team of researchers have explored the biochemical signal gradients on mesenchymal stem cells in 3D hydrogel cultures and have come up with exciting findings on the transition of these cells to bone or cartilage.Click to read more...

5. Unlimited in-vitro expansion of pancreatic stem cells from mice accomplished.

A team from the Netherlands have identified a methodology using which they could activate the Wnt signalling pathway for unlimited expansion of pancreatic stem cells isolated from mice. These stem cells could be of immense application in pancreatic disease including diabetes. Click to read more...

6. Reprogramming of cells inside a living mouse made possible – A scientific breakthrough

Reprogramming was so far performed in vitro. Now a team of scientists have demonstrated the reprogramming of cells to pluripotency inside a living mouse and the results showed that the induced pluripotent stem cells (iPS) induced inside the living mice were more primitive than those created in the lab. Click to read more...

7. Tumour regression after targeted Immunotherapy combined with Chemotherapy in advanced pancreatic cancer.

The results of a clinical trial in which standard chemotherapy using Gemcitabine when combined with targeted immunotherapy using CD40 antibody has shown substantial tumor regressions among some patients with advanced pancreatic cancer. Click to read more...

8. Novel drug to prevent cytomegalovirus (CMV) infection after blood stem cell transplant

A study published in the New England Journal of Medicine has reported that hematopoietic stem cell transplant recipients who are given the drug CMX001 shortly after the transplant have less chances of developing Cytomegalovirus (CMV) infection. CMV infection occurs in 3 to 5 % of the Allogenic transplant patients leading to various complications. Click to read more...

9. Transportation of Corneal stem cells without cool preservation made possible by novel nanopolymer

An Indo-Japan research initiative has lead to the development of a novel nanopolymer cocktail which helps in the transportation of corneal endothelium from faraway places to a central lab without cool preservation. The stem cells from these corneal endothelial tissues then could be in vitro expanded to treat corneal endothelial diseases. Click to read more...

10. Stem cells from the fat to enhance breast reconstruction surgery outcome

Scientists have reported that stem cell enriched fat grafts perform better with less tisse rejection than the traditional fat grafts used in breast reconstruction surgery. The stem cells in that study were obtained from the liposucted fat of the patients. Click to read more..

Really???

1. Did you know what a Genophore is? A genophore is the DNA of a prokaryote. The genophore is circular in most of the prokaryotes, and linear in a few. The circular nature of the Genophore helps the DNA replication to occur without telomeres which are needed to prevent the loss of information from the end of the chromosomes during cell divison in cells with linear chromosomes as found in eukaryotes.

2. Are you aware of the term 'The Weismann barrier'? It is a principle proposed by August Weismann which states that hereditary information can move only from germline cells to somatic cells and not in the reverse. Though widely criticized, this principle is important in gene therapy because if this barrier is permeable, then gene therapies targeted at somatic cells may lead to heritable changes in the genome which may result in genetic engineering of the human species rather than the individuals.
                                                                                                                                            -Information Source: Wikipedia

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