CURRENT STEM CELL NEWS

1. Single cell technology improves stem cell research

High throughput technology based on microraft array' (MRA) has helped scientists to view intestinal stem cells as single cells. Scientists were able to study influence of cell-contact of these stem cells with the Paneth cells or niche cells using this technology. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Stem cells and anti-diabetic medication help treat type 2 diabetes in mice

A combination of transplantation of encapsulated pancreatic progenitor cells derived from human embryonic stem cells and anti-diabetic medication has helped improve glucose levels after only 12 weeks in a Type II Diabetes mice model. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Cell based in vitro model identifies lethal prostate cancer subtypes

Scientists have knocked off two genes MAP3K, CHD1 in prostate stem cells grown in culture, then developed artificial prostate from these cells and grafted them into mouse models. The results showed that these mice developed the aggressive sub-type type of prostate cancer highlighting the role of these genes in the development of the lethal sub-type of prostate cancer. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Organoids models of distal airway epithelium created using stem cells

Induced pluripotent Stem cells derived from skins of cystic fibrosis patients have been used to grow distal airway epithelium organoid models of lung tissue. These organoids can be used for disease modeling and drug screening along with studying lung development. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Genomic library of embryonic stem cells employed to determine sensitivity and resistance to rabies virus infection

Researchers have used a genomic library of mutant murine embryonic stem cells (ESCs) and have cultured, differentiated the mutant clones from this library to identify host genes that are involved in sensitivity and resistance to rabies virus infection. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Novel RNA molecule that regulates the production of neurons from neural stem cells identified

A new long noncoding RNA (lncRNA) called Pinky (Pnky) has been identified as a neural specific lncRNA and its knockdown has been found to increase the neuronal differentiation in culture and in vivo. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. ID4 gene regulates breast stem cells and an aggressive form of triple-negative breast cancer, says study

Researchers have shown that a gene called "inhibitor of differentiation 4" (ID4) is an indicator of an highly aggressive form of triple-negative breast cancer and also it regulates the cancer by regulating the breast stem cell renewal. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Molecular pathway regulating blood stem cell aging discovered

Scientists have reported that when the levels of a sirtuin called SIRT7 is increased in blood stem cells taken from aged mice, they were able to reduce mitochondrial protein-folding stress and when these stem cells were transplanted back to mice, the regenerative capacity of the blood stem cells improved. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Differentiating blood cancer cells to normal immune cells accomplished - potential to treat aggressive blood cancer

It has been proven in a study that it is possible to reprogram cancerous cells from B cell acute lymphoblastic leukemia (B-ALL) patients to transform them into cells that resemble normal immune cells called macrophages and this differentiation therapy has great therapeutic potential in the future. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Sox 9 help preserve stem cell identity

New research has demonstrated that a protein called Sox9 play a key role in stem cell plasticity and this protein is responsible for the activation of genes associated with stem cell identity in the hair follicle. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that salamanders can regenerate complex structures including parts of their hearts, eyes, spinal cord, tails, and they are the only adult vertebrates that can regenerate their limbs fully?    
 -Source: http://www.ucl.ac.uk/news/news-articles/0614/200614-salamander-limb-regeneration#sthash.CblZFTCf.dpuf

2. Are you aware about RNA interference (RNAi)? It is a biological process in which RNA molecules inhibit gene expression by destroying specific mRNA molecules. It was Craig C. Mello and Andrew Fire who coined the term RNAi based on their report on gene silencing after injecting double stranded RNA into C. elegans. Mello and Fire were awarded the 2006 Nobel Prize in Physiology or Medicine for this work.    
 - Source: Wikipedia

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