CURRENT STEM CELL NEWS

1. Diversity of Gastrointestinal bacteria can predict the survival after stem cell transplant

Fecal samples from patients who underwent allogeneic stem cell transplantation were analyzed for gut microbiota diversity. It was observed that patients with high microbiota diversity had higher overall survival rates. Click to read more...

2. Miniature retina created using human stem cells in the lab

A 3D miniature of retina was created using human stem cells by researchers from John Hopkins University. They observed that the retina tissue grown in the lab had reached the equivalent of 28 weeks' development in the womb and the functional behavior was also similar to that of the native retinal tissue in humans. Click to read more...

3. Path taken by a stem cell during differentiation depends on 'wisdom of the crowd' - says study

Researchers from the Rice University have analyzed the differentiation of pluripotent stem cells using a 'Many-body' landscape based mathematical model. This stylish yet simplified model has given new insights into how cell networks function. Click to read more...

4. Role of Sox2 in regulating Skin cancer deciphered

Sox2 transcription factor has been shown to be involved in initiation and cancer stem cells function in skin squamous cell carcinoma. Deletion of this transcriptional factor has been observed to prevent this skin cancer initiation. Click to read more...

5. Virus specific T cells can protect post transplant patients against infections

A team of scientists have made virus specific T cells to protect against the infection caused by cytomegalovirus (CMV) virus during the post stem cell transplant period. Even very low dosages of these specific T cells have been shown to have efficacy against the infection. Click to read more...

6. Myeloproliferative disorders linked to genetic mutation that alters microenvironment of hematopoietic stem cell niche

Microenvironment controls the proliferation, differentiation and migration of the hematopoietic stem cells. A specific genetic mutation in the stem cells can cause inflammatory injury to the microenvironment making it lose the control over the stem cells leading to myeloproliferative neoplasias and hence treatments targeting the niche to reverse this damage can give rise to a new therapeutic approach. Click to read more...

7. Hydrogel encapsulated stem cells for enhancing bone repair

Researchers have demonstrated that stem cells encapsulated in a hydrogel remained at the lesion site without being washed away when transplanted for bone repair in mouse and the cells could attach to the bone as the hydrogel dissolved. Click to read more...

8. Reactive Oxygen species and lung airway stem cells explored

A recent study has shown that the low to moderate levels of reactive oxygen species (ROS) drives the repair process in lung airways by the stem cells present in them and when the levels of ROS increases, they are returned back to low levels to prevent excessive proliferation of the cells. Disrupting this regulation leads to lung cancer. Click to read more...

9. Spiral ganglion stem cells present in inner ear can restore hearing – suggests study

Spiral ganglion cells in the inner ear have been shown to possess self-renewing properties and hence are being considered as a potential cell source for regenerating neural structures of the inner ear in order to restore hearing. Click to read more...

10. Study offers insights on the role of CCL2 chemokine in the enhancement of stem cell pluripotency

As an alternative to cell culture protocols that employ components which have the risk of biological contamination, scientists by studying the role of CCL2 have identified that CCL2 can be used as a replacement of bFGF to maintain the pluripotency of the stem cells during cell culture. Click to read more...

Really???

1. We know that spaceflight blunts the immune system of humans and animals making them more vulnerable to infections. Are you aware that spaceflight also increases the virulence and resistance of bacteria like the Salmonella enterica serovar Typhimurium, which is among leading causes of human disease? This even more increases the risk of in-flight infectious disease.(Source: Nickerson et al Infect Immun. Jun 2000; 68(6): 3147–3152)

2. Did you know that before the discovery of Bacteriophages (viruses that can kill bacteria) by Frederick Twort in 1915 and independently by Felix d'Herelle in 1917, M. E. Hankin in 1896 had reported that the waters of the river Ganges and Jumna in India had marked antibacterial action against Vibrio Cholerae, the bacteria responsible for the disease, cholera and these waters continued to possess the anti-bacterial action even when passed through a very fine porcelain filter implying that the responsible agent was smaller than any known bacterium? Though this observation was not followed up further, this work was recognized a generation later as one of the first observations of bacteriophage activity.    (Source : Wikipedia and http://en.citizendium.org/wiki/Bacteriophage)

Creative Commons License All site content, except where otherwise noted is licensed under a Creative Commons Attribution 3.0 Unported License.