CURRENT STEM CELL NEWS

1. World's first clinical trial of iPS cells for Parkinsonism

Japanese scientists have announced that they will start clinical trials next month on a treatment for Parkinson's disease, transplanting dopamine-producing brain cells derived from induced pluripotent stem (iPS) cells into brains. Click to read more...

2. Stem cells self assemble to form mouse embryos

Three types of mouse stem cells: embryonic stem cells, extraembryonic trophoblast cells and primitive endoderm cells have been used along with a three dimensional scaffold which has resulted in the cells to self-assemble to gastrulating embryo-like structures. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Hypothalamus controls aging through exosomal miRNAs – says study

A study has identified that a narrow population of hypothalamic stem cell directly fight aging in the mouse via mechanisms involving exosomal microRNAs (miRNAs) in the cerebrospinal fluid. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Novel imaging technique helps study nanosacle blood stem cell interactions

Microfluidics-based super resolution fluorescence imaging has helped researchers study the nanoscale reorganisation of cell surface markers on blood stem cells which are essential for their adhesion and migration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. CRISP-R based iPS stem cell production

CRIPSRa gene editing method has been used to reprogramming human skin fibroblasts into induced pluripotent stem cells (iPSCs) targeting endogenous genes. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Stem cell reprogramming without external biochemical factors achieved

Laterally confined growth of cells has been shown to induce nuclear reprogramming to a stem cell state in the absence of exogenous biochemical factors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Key surface molecule controlling dental pulp stem cell renewal identified

PD-1 has been identified to be the key surface molecule controlling self-renewal and multipotential differentiation of Dental Mesenchymal Stem Cells from dental pulp of Deciduous Teeth (MSC-DT). Click to read more...

8. Scientists create Neanderthal mini-brains

Scientists have created mini brain organoids using skin cells donated by neurotypical individuals which were reprogrammed. In these reprogrammed cells, a gene called NOVA1 was edited using CRISPR/Cas9, to produce the Neanderthal version of the gene. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. iPS based disease model helps study Huntington's disease

Induced pluripotent stem cells derived from patients with Huntington's disease have been found to have ability to avoid the accumulation of toxic protein aggregates, a hallmark of the Huntington's disease and a protein called UBR5 was identified to be the underlying key factor. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Mechanism of conversion of one stem cell subtype to another identified using computational biology

Using Single-cell RNA sequencing a computational platform called TransSyn has been developed which has helped in identification of specific sets of transcription factors (TFs) that play major role in conversion of one stem cell sub-type to another . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. To answer why humans became the last surviving hominin species on the planet, a critical review of archaeological and palaeoenvironmental datasets relating to the Middle and Late Pleistocene (300-12 thousand years ago) ages has revealed that only Homo sapiens had the ability to occupy diverse and 'extreme' settings around the world stands in contrast to the ecological adaptations of other hominin species such as Homo erectus, Homo floresiensis, Homo Neanderthalensis etc.
 -Source: ScienceDaily, 30 July 2018 and Nature Human Behaviour, 2018; DOI: 10.1038/s41562-018-0394-4

2. It is possible to enhance your memory by a non-invasive brain stimulation technique delivered during sleep. The technique involves stimulation by using a closed-loop transcranial alternating current stimulation system matching the phase and frequency of ongoing slow-wave oscillations during sleep which will lead to better memory consolidations between the hippocampus to the neocortex.     
-Source: ScienceDaily, 23 July 2018 and he Journal of Neuroscience, 2018; 0273-18 DOI: 10.1523/JNEUROSCI.0273-18.2018

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