CURRENT STEM CELL NEWS

1. Stem Cells help reverse learning and memory deficits after chemotherapy

In an animal study it has been proven that neural stem cells help to reverse learning and memory deficits after chemotherapy. The stem cells help in healing by survival and differentiated into multiple neural cell types and secretion of neurotrophic growth factors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Cilia structure influences stem cell differentiation into fat cell

Length of the primary cilia structure regulates stem cell differentiation into fat cell according to a new study which showed that reduced expression of a specific gene prevented cilia elongation and cells with shorter cilia did not differentiate into fat cell. This study will help in formulating cilia-targeted therapies for treating conditions such as obesity. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Cancer detection test based on sniffing ability of roundworms developed in Japan

Hitachi and Kyushu University researchers have developed a novel cancer detecting tool in which the round worms are allowed to react to the urine of people. Since round worms are attracted to urine of cancer patients the test is based on analysis of movements of the 100 or so round worms. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Gel encapsulation and immune cell repelling protein for preventing rejection of transplanted pancreatic cells

Islets from non-diabetic encapsulated using a CXCL12-containing gel have been shown to survive and maintain the blood glucose levels for long term after transplantation in Diabetic mice. CXCL12 prevents rejection of the transplanted islets by repelling the effector T cells responsible for the rejection. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. State of Dormancy protects blood stem cell from DNA damage- reports study

A recent study has demonstrated that the blood stem cells are prevented from DNA damage when they are in a state of dormancy. Under conditions of stress, since the stem cells are pushed to a state of rapid cell division there is increased likelihood of DNA damage, death of the stem cells, or the cells mutations leading to cancer. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Gene Regulatory pathways behind aggressive pediatric brain cancer studied

Two genes LIN28 and HMGA2 have been identified by scientists to play a major role in cell growth and resistance to anticancer treatment of atypical teratoid/rhabdoid tumor (AT/RT), an aggressive childhood brain tumour. When these two genes based pathways were blocked, it resulted in increased cell death of the cancer cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Adult human Skin cells and stem cells paired to create germ line cells - Potential to create babies for same sex couples

In a novel approach, stem cells and adult human skin cells have been combined create an new germ-cell line. The germ cell line is capable of giving rise to sperm cells and eggs which can be used to create an embryo. It has been identified that SOX17 gene is critical for pairing of the stem cells and skin cells and is a key regulator of reprogramming of the cells. This technology can help to create eggs and sperms from skin cells of two adults of the same gender helping them to have a baby. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Vitamin A regulates blood stem cells development - shows study

An in vitro human model of embryonic blood stem cell development has reported that increased levels of Vitamin A (retinoic acid) reduce the number of blood cells that could be produced from the blood stem cells. A reduction in the retinoic acid increased the production of blood cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Graphene to target and eliminate cancer stem cells

A novel study has suggested that the graphene, a Nanomaterial made of thin flakes of carbon can eliminate cancer stem cells efficiently by preventing the tumor sphere formation from these cancer stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Study on eye morphogenesis in fish describes origin and flow of its stem cells

4D microscopy has enabled scientists to study the directed tissue flow which transforms the optic vesicle to become the optic cup during development of the eye in fishes. The study also describes how the stem cells flow from their origin to the optic cup. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that in addition to longevity turtles also possess unique characteristics like resistance to grow old, reproduction even at advanced stage, slow evolution and ability to freeze and thaw their bodies without damage to even the delicate organs? Scientists by studying the genome of the turtle have identified that these physiological adaptations in turtle can be attributed to their nature of adapting existing genes for new uses. It has also been shown that nearly 19 genes in the brain and 23 in the heart of the turtle are activated during low-oxygen conditions     
                          
  - Source: Michele Munz. Turtle genome offers clues to longevity, surviving without oxygen. St. Louis Post Dispatch and Shaffer et al. Genome Biology 2013

2. Microchimerism or the persistent presence of genetically distinct cells in an organism is a topic being widely researched in recent times. It has been identified that microchimeric cells persist not only in the circulation of mothers after pregnancy but they also get embedded in their brains. Women have been found to possess microchimeric cells both from their mother as well as from their own pregnancies with ensuing competition between the grandmother's and infant's cells. Also a paradoxical finding is that Alzheimer's disease is more common in women who have had multiple pregnancies but microchimeric cells are less common in the brains of these women.    
                           - Source: Robert Martone. Scientists Discover Children's Cells Living in Mothers' Brains. Scientific American. December 4, 2012

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